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    tsx nucleoside-specific channel-forming protein Tsx [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946242, updated on 3-Dec-2024

    Summary

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    Official Symbol
    tsx
    Official Full Name
    nucleoside-specific channel-forming protein Tsx
    Primary source
    ECOCYC:EG11035
    Locus tag
    b0411
    See related
    ASAP:ABE-0001425
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0405; nupA; T6rec
    Summary
    First 22 aa are predicted to be a type I signal peptide. [More information is available at EcoGene: EG11035]. Tsx is a protein involved with the permeation of ribo- and deoxy-nucleosides, across the outer membrane of Escherichia coli. [More information is available at EcoCyc: EG11035].
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    Genomic context

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    Sequence:
    NC_000913.3 (431129..432013, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene Sec translocon accessory complex subunit SecF Neighboring gene HNH nuclease family protein YajD Neighboring gene putative lipoprotein YajI Neighboring gene NrdR transcriptional repressor

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Outer membrane of Escherichia coli K-12: TSX mutants (resistant to bacteriophage T6 and colicin K) lack an outer membrane protein. Manning PA, et al. Biochem Biophys Res Commun, 1976 Jul 26. PMID 786287
    2. Stable albicidin resistance in Escherichia coli involves an altered outer-membrane nucleoside uptake system. Birch RG, et al. J Gen Microbiol, 1990 Jan. PMID 2191080
    3. Single amino acid substitutions affecting the substrate specificity of the Escherichia coli K-12 nucleoside-specific Tsx channel. Fsihi H, et al. J Biol Chem, 1993 Aug 15. PMID 8349629
    4. Crystal structure of the bacterial nucleoside transporter Tsx. Ye J, et al. EMBO J, 2004 Aug 18. PMID 15272310, Free PMC Article
    5. Identification of a segment of the Escherichia coli Tsx protein that functions as a bacteriophage receptor area. Schneider H, et al. J Bacteriol, 1993 May. PMID 8491700, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. crystal structures of Escherichia coli Tsx in the absence and presence of nucleosides
      Title: Crystal structure of the bacterial nucleoside transporter Tsx.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables nucleoside transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleoside-specific channel forming porin activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables porin activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleoside transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within nucleoside transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within symbiont entry into host cell IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of pore complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of pore complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    nucleoside-specific channel-forming protein Tsx

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      431129..432013 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414945.1 nucleoside-specific channel-forming protein Tsx [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414945.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A2W6PV85, A0A5B9AL25, A0A6L7CJP7
      Conserved Domains (1) summary
      PRK15106
      Location:1 → 294
      PRK15106; nucleoside-specific channel-forming protein Tsx; Provisional
    Nucleotide Protein
    Heading Accession and Version

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