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    lpxH UDP-2,3-diacylglucosamine diphosphatase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 949053, updated on 3-Dec-2024

    Summary

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    Official Symbol
    lpxH
    Official Full Name
    UDP-2,3-diacylglucosamine diphosphatase
    Primary source
    ECOCYC:EG12666
    Locus tag
    b0524
    See related
    ASAP:ABE-0001804
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0517; ybbF
    Summary
    UDP-2,3-diacylglucosamine hydrolase (LpxH) catalyzes the fourth step in lipid A synthesis. [More information is available at EcoCyc: EG12666].
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    Genomic context

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    Sequence:
    NC_000913.3 (553218..553940, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF2877 domain-containing protein YlbF Neighboring gene putative carbamate kinase Neighboring gene 5-(carboxyamino)imidazole ribonucleotide synthase Neighboring gene N(5)-carboxyaminoimidazole ribonucleotide mutase Neighboring gene peptidyl-prolyl cis-trans isomerase B Neighboring gene cysteine--tRNA ligase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Fatty acyl derivatives of glucosamine 1-phosphate in Escherichia coli and their relation to lipid A. Complete structure of A diacyl GlcN-1-P found in a phosphatidylglycerol-deficient mutant. Takayama K, et al. J Biol Chem, 1983 Jun 25. PMID 6345522
    2. Identification and sequence analysis of Escherichia coli purE and purK genes encoding 5'-phosphoribosyl-5-amino-4-imidazole carboxylase for de novo purine biosynthesis. Watanabe W, et al. J Bacteriol, 1989 Jan. PMID 2644189, Free PMC Article
    3. Biosynthesis, transport, and modification of lipid A. Trent MS. Biochem Cell Biol, 2004 Feb. PMID 15052329
    4. Lipid A modification systems in gram-negative bacteria. Raetz CR, et al. Annu Rev Biochem, 2007. PMID 17362200, Free PMC Article
    5. Lipopolysaccharide endotoxins. Raetz CR, et al. Annu Rev Biochem, 2002. PMID 12045108, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. confirmed biochemically that LpxH is inhibited by a previously identified antibacterial compound, determined the potency of this inhibitor, and modeled its binding mode in the LpxH active site
      Title: The substrate-binding cap of the UDP-diacylglucosamine pyrophosphatase LpxH is highly flexible, enabling facile substrate binding and product release.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables UDP-2,3-diacylglucosamine hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables UDP-2,3-diacylglucosamine hydrolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables UDP-2,3-diacylglucosamine hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables UDP-2,3-diacylglucosamine hydrolase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables manganese ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables manganese ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pyrophosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid A biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipid A biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in lipid A biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lipid A biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extrinsic component of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    UDP-2,3-diacylglucosamine diphosphatase
    NP_415057.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      553218..553940 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415057.1 UDP-2,3-diacylglucosamine diphosphatase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415057.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A377DXC5
      Conserved Domains (1) summary
      PRK05340
      Location:1 → 240
      PRK05340; UDP-2,3-diacylglucosamine hydrolase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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