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    sucB dihydrolipoyltranssuccinylase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945307, updated on 3-Dec-2024

    Summary

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    Official Symbol
    sucB
    Official Full Name
    dihydrolipoyltranssuccinylase
    Primary source
    ECOCYC:EG10980
    Locus tag
    b0727
    See related
    ASAP:ABE-0002480
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0715
    Summary
    sucAB is a synthetic lethal with sucCD. [More information is available at EcoGene: EG10980]. The SucB subunit (E2o) of the 2-oxoglutarate dehydrogenase complex is responsible for the dihydrolipoamide succinyltransferase activity . [More information is available at EcoCyc: EG10980].
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    Genomic context

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    Sequence:
    NC_000913.3 (761522..762739)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene succinate:quinone oxidoreductase, iron-sulfur cluster binding protein Neighboring gene subunit of E1(0) component of 2-oxoglutarate dehydrogenase Neighboring gene succinyl-CoA synthetase subunit beta Neighboring gene succinyl-CoA synthetase subunit alpha

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Three-dimensional solution structure of the E3-binding domain of the dihydrolipoamide succinyltransferase core from the 2-oxoglutarate dehydrogenase multienzyme complex of Escherichia coli. Robien MA, et al. Biochemistry, 1992 Apr 7. PMID 1554728
    2. Escherichia coli pyruvate dehydrogenase complex. Thiamin pyrophosphate-dependent inactivation by 3-bromopyruvate. Apfel MA, et al. J Biol Chem, 1984 Mar 10. PMID 6365919
    3. Three-dimensional structure of the lipoyl domain from the dihydrolipoyl succinyltransferase component of the 2-oxoglutarate dehydrogenase multienzyme complex of Escherichia coli. Ricaud PM, et al. J Mol Biol, 1996 Nov 22. PMID 8950276
    4. Crystal structure of the truncated cubic core component of the Escherichia coli 2-oxoglutarate dehydrogenase multienzyme complex. Knapp JE, et al. J Mol Biol, 1998 Jul 24. PMID 9677295
    5. All-atom replica exchange molecular simulation of protein BBL. Zhang J, et al. Proteins, 2008 Aug 15. PMID 18320591

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. sucB and ubiF mutants deficient in energy production were identified from the mutant screens to have defective persister survival as demonstrated by higher susceptibility to various antibiotics and different stresses.
      Title: Energy production genes sucB and ubiF are involved in persister survival and tolerance to multiple antibiotics and stresses in Escherichia coli.
    2. N-terminus verified by Edman degradation on mature peptide
      Title: Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12.
    3. sucAB and sucCD are mutually essential genes for production of succinyl Coa that is essential for cell viability
      Title: sucAB and sucCD are mutually essential genes in Escherichia coli.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dihydrolipoyllysine-residue succinyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dihydrolipoyllysine-residue succinyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables dihydrolipoyllysine-residue succinyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dihydrolipoyllysine-residue succinyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables lipoic acid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in L-lysine catabolic process to acetyl-CoA via saccharopine IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tricarboxylic acid cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tricarboxylic acid cycle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in tricarboxylic acid cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within tricarboxylic acid cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of oxoglutarate dehydrogenase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of oxoglutarate dehydrogenase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of oxoglutarate dehydrogenase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dihydrolipoyltranssuccinylase
    NP_415255.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      761522..762739
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415255.1 dihydrolipoyltranssuccinylase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415255.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A6C9QAQ1, A0A8S7ENK5
      Conserved Domains (1) summary
      PRK05704
      Location:2 → 405
      PRK05704; 2-oxoglutarate dehydrogenase complex dihydrolipoyllysine-residue succinyltransferase
    Nucleotide Protein
    Heading Accession and Version

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