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    helD DNA helicase IV [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946227, updated on 3-Dec-2024

    Summary

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    Official Symbol
    helD
    Official Full Name
    DNA helicase IV
    Primary source
    ECOCYC:EG10426
    Locus tag
    b0962
    See related
    ASAP:ABE-0003257
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0953; srjB
    Summary
    Overexpression causes filamentous biofilm formation. [More information is available at EcoGene: EG10426]. The HelD protein, DNA helicase IV, is an ATP-dependent 3'-to-5' DNA helicase involved in the RecF pathway of recombination . [More information is available at EcoCyc: EG10426].
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    Genomic context

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    Sequence:
    NC_000913.3 (1024471..1026525)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene transcriptional coactivator for CRP Neighboring gene putative transporter YccS Neighboring gene PF03733 family inner membrane protein YccF Neighboring gene methylglyoxal synthase Neighboring gene DUF2057 domain-containing protein YccT

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Study of the ATP-binding site of helicase IV from Escherichia coli. Dubaele S, et al. Biochem Biophys Res Commun, 2006 Mar 17. PMID 16442499
    2. Purification and characterization of a new DNA-dependent ATPase with helicase activity from Escherichia coli. Wood ER, et al. J Biol Chem, 1987 Nov 5. PMID 2822720
    3. Double helicase II (uvrD)-helicase IV (helD) deletion mutants are defective in the recombination pathways of Escherichia coli. Mendonca VM, et al. J Bacteriol, 1993 Aug. PMID 8335623, Free PMC Article
    4. Genetic analysis of delta helD and delta uvrD mutations in combination with other genes in the RecF recombination pathway in Escherichia coli: suppression of a ruvB mutation by a uvrD deletion. Mendonca VM, et al. Genetics, 1995 Oct. PMID 8647383, Free PMC Article
    5. Suppression of recJ exonuclease mutants of Escherichia coli by alterations in DNA helicases II (uvrD) and IV (helD). Lovett ST, et al. Genetics, 1995 May. PMID 7635292, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on complete protein
      Title: The molecular cloning of the gene encoding the Escherichia coli 75-kDa helicase and the determination of its nucleotide sequence and gentic map position.
    2. helicase IV from Escherichia coli, utilizes a conserved glutamine and conserved aromatic residue to interact with ATP
      Title: Study of the ATP-binding site of helicase IV from Escherichia coli.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 3'-5' DNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3'-5' DNA helicase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent H2AZ histone chaperone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent H3-H4 histone complex chaperone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA clamp loader activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin extrusion motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cohesin loader activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables double-stranded DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables forked DNA-dependent helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables four-way junction helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables single-stranded 3'-5' DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA duplex unwinding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin looping IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in recombinational repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA helicase IV

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1024471..1026525
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415482.1 DNA helicase IV [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415482.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A895P2F6
      Conserved Domains (1) summary
      PRK11054
      Location:1 → 684
      helD; DNA helicase IV; Provisional
    Nucleotide Protein
    Heading Accession and Version

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