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    solA N-methyl-L-tryptophan oxidase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 944983, updated on 3-Dec-2024

    Summary

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    Official Symbol
    solA
    Official Full Name
    N-methyl-L-tryptophan oxidase
    Primary source
    ECOCYC:G6556
    Locus tag
    b1059
    See related
    ASAP:ABE-0003590
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1044
    Summary
    SolA has weak activity on carbinolamines, sarcosine and other secondary amino acids. [More information is available at EcoGene: EG12669]. The solA gene product has N-methyltryptophan oxidase (MTOX) activity. [More information is available at EcoCyc: G6556].
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    Genomic context

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    Sequence:
    NC_000913.3 (1119468..1120586, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative cytochrome b561 YceJ Neighboring gene DUF2770 domain-containing protein YceO Neighboring gene regulator of biofilm formation Neighboring gene DNA damage-inducible protein I

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Pleiotropic impact of a single lysine mutation on biosynthesis of and catalysis by N-methyltryptophan oxidase. Bruckner RC, et al. Biochemistry, 2011 Jun 7. PMID 21526853, Free PMC Article
    2. pH and kinetic isotope effects on sarcosine oxidation by N-methyltryptophan oxidase. Ralph EC, et al. Biochemistry, 2005 Mar 1. PMID 15723552, Free PMC Article
    3. Tautomeric rearrangement of a dihydroflavin bound to monomeric sarcosine oxidase or N-methyltryptophan oxidase. Khanna P, et al. Biochemistry, 2003 Feb 4. PMID 12549903
    4. N-methyltryptophan oxidase from Escherichia coli: reaction kinetics with N-methyl amino acid and carbinolamine substrates. Khanna P, et al. Biochemistry, 2001 Feb 6. PMID 11170473
    5. Characterization of the FAD-containing N-methyltryptophan oxidase from Escherichia coli. Khanna P, et al. Biochemistry, 2001 Feb 6. PMID 11170472

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Lys259 is the site of oxygen activation in MTOX and also plays a role in holoenzyme biosynthesis and N-methyltryptophan oxidation
      Title: Pleiotropic impact of a single lysine mutation on biosynthesis of and catalysis by N-methyltryptophan oxidase.
    2. an examination of kinetic properties and substrate specificity.an examination of kinetic properties and substrate specificity.
      Title: pH and kinetic isotope effects on sarcosine oxidation by N-methyltryptophan oxidase.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables N-methyl-L-amino-acid oxidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables N-methyl-L-amino-acid oxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables flavin adenine dinucleotide binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sarcosine oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    N-methyl-L-tryptophan oxidase
    NP_415577.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1119468..1120586 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415577.1 N-methyl-L-tryptophan oxidase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415577.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A5B9AKZ8, A0A8T6BDZ9
      Conserved Domains (1) summary
      PRK11259
      Location:1 → 372
      solA; N-methyl-L-tryptophan oxidase
    Nucleotide Protein
    Heading Accession and Version

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