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    fabG 3-oxoacyl-[acyl-carrier-protein] reductase FabG [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945645, updated on 17-Dec-2024

    Summary

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    Official Symbol
    fabG
    Official Full Name
    3-oxoacyl-[acyl-carrier-protein] reductase FabG
    Primary source
    ECOCYC:EG11318
    Locus tag
    b1093
    See related
    ASAP:ABE-0003700
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1079
    Summary
    FabG converts ethyl 4-chloroacetoacetate (ECAA) to ethyl ( S)-4-chloro-3-hydroxybutanoate (ECHB) in vitro. [More information is available at EcoGene: EG11318]. Cotranscribed with acpP. [More information is available at EcoCyc: EG11318].
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    Genomic context

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    Sequence:
    NC_000913.3 (1150670..1151404)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene 3-oxoacyl-[acyl carrier protein] synthase 3 Neighboring gene [acyl-carrier-protein] S-malonyltransferase Neighboring gene acyl carrier protein Neighboring gene 3-oxoacyl-[acyl carrier protein] synthase 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Escherichia coli FabG 3-ketoacyl-ACP reductase proteins lacking the assigned catalytic triad residues are active enzymes. Hu Z, et al. J Biol Chem, 2021 Jan-Jun. PMID 33545175, Free PMC Article
    2. Novel inhibitors of beta-ketoacyl-ACP reductase from Escherichia coli. Kristan K, et al. Chem Biol Interact, 2009 Mar 16. PMID 18977209
    3. FabG mediates polyhydroxyalkanoate production from both related and nonrelated carbon sources in recombinant Escherichia coli LS5218. Nomura CT, et al. Biotechnol Prog, 2008 Mar-Apr. PMID 18215055
    4. Structure of beta-ketoacyl-[acyl carrier protein] reductase from Escherichia coli: negative cooperativity and its structural basis. Price AC, et al. Biochemistry, 2001 Oct 30. PMID 11669613
    5. Synthesis of ethyl ( S)-4-chloro-3-hydroxybutanoate using fabG-homologues. Yamamoto H, et al. Appl Microbiol Biotechnol, 2003 Apr. PMID 12655455

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Escherichia coli FabG 3-ketoacyl-ACP reductase proteins lacking the assigned catalytic triad residues are active enzymes.
      Title: Escherichia coli FabG 3-ketoacyl-ACP reductase proteins lacking the assigned catalytic triad residues are active enzymes.
    2. FabG1 activity can be replaced by the corresponding enzyme from the closely related species Mycobacterium smegmatis but not by the enzyme from Escherichia coli
      Title: Functional complementation of the essential gene fabG1 of Mycobacterium tuberculosis by Mycobacterium smegmatis fabG but not Escherichia coli fabG.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NADP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within biotin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within fatty acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in fatty acid elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid elongation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within lipid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    3-oxoacyl-[acyl-carrier-protein] reductase FabG
    NP_415611.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1150670..1151404
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415611.1 3-oxoacyl-[acyl-carrier-protein] reductase FabG [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415611.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A5B9ANE5
      Conserved Domains (1) summary
      PRK05557
      Location:1 → 244
      fabG; 3-ketoacyl-(acyl-carrier-protein) reductase; Validated
    Nucleotide Protein
    Heading Accession and Version

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