narJ nitrate reductase 1 molybdenum cofactor assembly chaperone [Escherichia coli str. K-12 substr. MG1655] - Gene

Summary

Official Symbol: narJ
Official Full Name: nitrate reductase 1 molybdenum cofactor assembly chaperone
Primary source: ECOCYC:EG10641
Locus tag: b1226
See related: ASAP:ABE-0004123
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage: Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as: ECK1220
Summary: NarJ has two NarG binding sites: one for Mo insertion and one to block membrane attachment via NarI until activation is complete. [More information is available at EcoGene: EG10641]. NarJ is parto of the redox enzyme maturation protein (REMP) family of chaperones . [More information is available at EcoCyc: EG10641].
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NC_000913.3 Genomic Context describing neighboring genes

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NarJ associated with a peptide of the first 50 residues of nitrate reductase catalytic subunit NarG.
Title: In vivo associations of Escherichia coli NarJ with a peptide of the first 50 residues of nitrate reductase catalytic subunit NarG.
Data demonstrate that NarJ has a multifunctional role in nitrate reductase A biosynthesis, as it orchestrates both the maturation and the assembly steps.
Title: Biogenesis of a respiratory complex is orchestrated by a single accessory protein.
The interactome of NarJ exhibits Tat-dependence.
Title: Twin-arginine translocase may have a role in the chaperone function of NarJ from Escherichia coli.
the NarJ chaperone interacts at two distinct binding sites of the apoenzyme
Title: NarJ chaperone binds on two distinct sites of the aponitrate reductase of Escherichia coli to coordinate molybdenum cofactor insertion and assembly.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables metallochaperone activity	IBA Inferred from Biological aspect of Ancestor more info
enables metallochaperone activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables unfolded protein binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chaperone-mediated protein complex assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in chaperone-mediated protein complex assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in chaperone-mediated protein complex assembly	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chaperone-mediated protein complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nitrate assimilation	IBA Inferred from Biological aspect of Ancestor more info
involved_in nitrate assimilation	IDA Inferred from Direct Assay more info	PubMed
involved_in nitrate assimilation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

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The following sections contain reference sequences that belong to a specific genome build. Explain