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    puuE 4-aminobutyrate aminotransferase PuuE [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945446, updated on 3-Dec-2024

    Summary

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    Official Symbol
    puuE
    Official Full Name
    4-aminobutyrate aminotransferase PuuE
    Primary source
    ECOCYC:G6646
    Locus tag
    b1302
    See related
    ASAP:ABE-0004380
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1297; goaG
    Summary
    PuuE was identified as a putrescine-inducible GABA aminotransferase, which allows cells to grow on putrescine as the sole source of nitrogen even in the absence of GabT . [More information is available at EcoCyc: G6646].
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    Genomic context

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    Sequence:
    NC_000913.3 (1365550..1366815)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase Neighboring gene gamma-glutamylputrescine oxidase Neighboring gene DNA-binding transcriptional dual regulator PspF Neighboring gene phage shock protein A

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Spot 42 RNA regulates putrescine catabolism in Escherichia coli by controlling the expression of puuE at the post-transcription level. Sun X, et al. J Microbiol, 2021 Feb. PMID 33527317
    2. A putrescine-inducible pathway comprising PuuE-YneI in which gamma-aminobutyrate is degraded into succinate in Escherichia coli K-12. Kurihara S, et al. J Bacteriol, 2010 Sep. PMID 20639325, Free PMC Article
    3. The RIB element in the goaG-pspF intergenic region of Escherichia coli. Jovanovic G, et al. J Bacteriol, 1997 May. PMID 9150200, Free PMC Article
    4. A novel putrescine utilization pathway involves gamma-glutamylated intermediates of Escherichia coli K-12. Kurihara S, et al. J Biol Chem, 2005 Feb 11. PMID 15590624
    5. A 570-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 28.0-40.1 min region on the linkage map. Aiba H, et al. DNA Res, 1996 Dec 31. PMID 9097039

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Spot 42 RNA regulates putrescine catabolism in Escherichia coli by controlling the expression of puuE at the post-transcription level.
      Title: Spot 42 RNA regulates putrescine catabolism in Escherichia coli by controlling the expression of puuE at the post-transcription level.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 4-aminobutyrate:2-oxoglutarate transaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pyridoxal phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pyridoxal phosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in gamma-aminobutyric acid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in gamma-aminobutyric acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within putrescine catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    4-aminobutyrate aminotransferase PuuE
    NP_415818.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1365550..1366815
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415818.1 4-aminobutyrate aminotransferase PuuE [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415818.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8H9XUT6, A0A8T6PS95
      Conserved Domains (1) summary
      PRK09792
      Location:1 → 421
      PRK09792; 4-aminobutyrate transaminase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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