fliA RNA polymerase sigma factor FliA [Escherichia coli str. K-12 substr. MG1655] - Gene

Summary

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Official Symbol: fliA
Official Full Name: RNA polymerase sigma factor FliA
Primary source: ECOCYC:EG11355
Locus tag: b1922
See related: ASAP:ABE-0006396
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage: Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as: ECK1921; flaD; rpoF
Summary: Sigma 28 is a minor sigma factor responsible for initiation of transcription at a number of genes involved in motility. [More information is available at EcoCyc: EG11355].
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Genomic context

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Sequence:: NC_000913.3 (2001070..2001789, complement)

NC_000913.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Temperature-Dependent Influence of FliA Overexpression on PHL628 E. coli Biofilm Growth and Composition.
Title: Temperature-Dependent Influence of FliA Overexpression on PHL628 E. coli Biofilm Growth and Composition.
Interactions between DksA and Stress-Responsive Alternative Sigma Factors Control Inorganic Polyphosphate Accumulation in Escherichia coli.
Title: Interactions between DksA and Stress-Responsive Alternative Sigma Factors Control Inorganic Polyphosphate Accumulation in Escherichia coli.
FliA is part of flagellar regulatory network.
Title: Comprehensive mapping of the Escherichia coli flagellar regulatory network.
Expression of the flagellar sigma(F) factor (FliA), another sigma(70) family protein, is controlled positively by RpoN but negatively by RpoS.
Title: Antagonistic regulation of motility and transcriptome expression by RpoN and RpoS in Escherichia coli.
The authors report that the crp--sigma F--RNA polymerase--aer promoter open complex is organized differently from complexes at previously characterized promoters.
Title: Activation of sigma 28-dependent transcription in Escherichia coli by the cyclic AMP receptor protein requires an unusual promoter organization.
Survival of fliA-mutants is apparently due to a decreased physical stress linked to the insertion of the flagellum through the membrane and energy saved through the loss of the motor proteins.
Title: Mutations in two global regulators lower individual mortality in Escherichia coli.
FlgM modulates FliA proteolysis.
Title: Cellular levels and activity of the flagellar sigma factor FliA of Escherichia coli are controlled by FlgM-modulated proteolysis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by EcoCyc

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-directed 5'-3' RNA polymerase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sigma factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables sigma factor activity	IDA Inferred from Direct Assay more info	PubMed
enables sigma factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in DNA-templated transcription initiation	IDA Inferred from Direct Assay more info	PubMed
involved_in DNA-templated transcription initiation	IEA Inferred from Electronic Annotation more info
involved_in bacterial-type flagellum assembly	NAS Non-traceable Author Statement more info	PubMed
involved_in bacterial-type flagellum-dependent cell motility	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA-templated transcription initiation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA-templated transcription initiation	IEA Inferred from Electronic Annotation more info
involved_in regulation of gene expression	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
part_of cytosolic DNA-directed RNA polymerase complex	IPI Inferred from Physical Interaction more info	PubMed

General protein information

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Preferred Names: RNA polymerase sigma factor FliA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_000913.3 Reference assembly

Range

2001070..2001789 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NP_416432.3 RNA polymerase sigma factor FliA [Escherichia coli str. K-12 substr. MG1655]

See identical proteins and their annotated locations for NP_416432.3

Status: PROVISIONAL

UniProtKB/TrEMBL

A0A418GSK7

Conserved Domains (1) summary

PRK06986
Location:4 → 237

fliA; flagellar biosynthesis sigma factor; Validated