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    menC o-succinylbenzoate synthase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946734, updated on 17-Dec-2024

    Summary

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    Official Symbol
    menC
    Official Full Name
    o-succinylbenzoate synthase
    Primary source
    ECOCYC:EG11532
    Locus tag
    b2261
    See related
    ASAP:ABE-0007473
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2255
    Summary
    O-succinylbenzoate synthase catalyzes the formation of the first aromatic intermediate of the menaquinone biosynthetic pathway by dehydration of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate . [More information is available at EcoCyc: EG11532].
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    Genomic context

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    Sequence:
    NC_000913.3 (2375000..2375962, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene lipid IVA 4-amino-4-deoxy-L-arabinosyltransferase Neighboring gene undecaprenyl-phosphate-alpha-L-Ara4N flippase - ArnE subunit Neighboring gene undecaprenyl-phosphate-alpha-L-Ara4N flippase - ArnF subunit Neighboring gene signal transduction protein PmrD Neighboring gene o-succinylbenzoate--CoA ligase Neighboring gene 1,4-dihydroxy-2-naphthoyl-CoA synthase Neighboring gene 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase Neighboring gene 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Stability for function trade-offs in the enolase superfamily "catalytic module". Nagatani RA, et al. Biochemistry, 2007 Jun 12. PMID 17503785
    2. Menaquinone biosynthesis: mutants of Escherichia coli K-12 requiring 2-succinylbenzoate. Guest JR. J Bacteriol, 1977 Jun. PMID 324971, Free PMC Article
    3. Evolution of enzymatic activity in the enolase superfamily: structure of o-succinylbenzoate synthase from Escherichia coli in complex with Mg2+ and o-succinylbenzoate. Thompson TB, et al. Biochemistry, 2000 Sep 5. PMID 10978150
    4. The lesser "burden borne" by o-succinylbenzoate synthase: an "easy" reaction involving a carboxylate carbon acid. Taylor EA, et al. J Am Chem Soc, 2001 Jun 20. PMID 11403626
    5. Evolution of enzymatic activity in the enolase superfamily: structural and mutagenic studies of the mechanism of the reaction catalyzed by o-succinylbenzoate synthase from Escherichia coli. Klenchin VA, et al. Biochemistry, 2003 Dec 16. PMID 14661953

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The results showed that E. coli K12 carrying a deletion of either the menD, menC or menE gene was unable to reduce selenate.
      Title: Role of menaquinone biosynthesis genes in selenate reduction by Enterobacter cloacae SLD1a-1 and Escherichia coli K12.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables O-succinylbenzoate synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydro-lyase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydro-lyase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hydro-lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in menaquinone biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in menaquinone biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within menaquinone biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    o-succinylbenzoate synthase
    NP_416764.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2375000..2375962 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416764.1 o-succinylbenzoate synthase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416764.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A2W6QWZ0
      Conserved Domains (1) summary
      COG1441
      Location:1 → 320
      MenC; O-succinylbenzoate synthase [Coenzyme transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version

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