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    hemF coproporphyrinogen III oxidase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946908, updated on 3-Dec-2024

    Summary

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    Official Symbol
    hemF
    Official Full Name
    coproporphyrinogen III oxidase
    Primary source
    ECOCYC:EG12189
    Locus tag
    b2436
    See related
    ASAP:ABE-0008034
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2431; popB; sec
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    Genomic context

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    Sequence:
    NC_000913.3 (2553225..2554124)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative inner membrane protein Neighboring gene putative acetyltransferase YpeA Neighboring gene N-acetylmuramoyl-L-alanine amidase A Neighboring gene putative DNA-binding transcriptional regulator EutR Neighboring gene putative structural protein, ethanolamine utilization microcompartment

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The induction of two biosynthetic enzymes helps Escherichia coli sustain heme synthesis and activate catalase during hydrogen peroxide stress. Mancini S, et al. Mol Microbiol, 2015 May. PMID 25664592, Free PMC Article
    2. Oxygen-dependent coproporphyrinogen-III oxidase from Escherichia coli: one-step purification and biochemical characterisation. Macieira S, et al. FEMS Microbiol Lett, 2003 Sep 12. PMID 13129604
    3. Oxygen-dependent coproporphyrinogen III oxidase (HemF) from Escherichia coli is stimulated by manganese. Breckau D, et al. J Biol Chem, 2003 Nov 21. PMID 12975365
    4. Identification and characterization of hydrogen peroxide-sensitive mutants of Escherichia coli: genes that require OxyR for expression. Mukhopadhyay S, et al. J Bacteriol, 1997 Jan. PMID 8990283, Free PMC Article
    5. Cloning and characterization of the Escherichia coli hemN gene encoding the oxygen-independent coproporphyrinogen III oxidase. Troup B, et al. J Bacteriol, 1995 Jun. PMID 7768836, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables coproporphyrinogen oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables coproporphyrinogen oxidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables coproporphyrinogen oxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables coproporphyrinogen oxidase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables manganese ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables manganese ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables tetrapyrrole binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in heme biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within heme biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in porphyrin-containing compound biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protoporphyrinogen IX biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protoporphyrinogen IX biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protoporphyrinogen IX biosynthetic process from glutamate EXP
    Inferred from Experiment
    more info
    		 PubMed 
    acts_upstream_of_or_within response to hydroperoxide IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to hydroperoxide IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    coproporphyrinogen III oxidase
    NP_416931.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2553225..2554124
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416931.1 coproporphyrinogen III oxidase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416931.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A0E2L2S8, A0A0H3EM02, A0A192C9I3, A0A1V1GAW9, A0A7H4YLG3, A0A8S7E9P6, A0AA36KZD7, F4T1N1, Q1R8T5, S1PYB0
      Conserved Domains (1) summary
      PRK05330
      Location:1 → 299
      PRK05330; oxygen-dependent coproporphyrinogen oxidase
    Nucleotide Protein
    Heading Accession and Version

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