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    hcaD putative 3-phenylpropionate/cinnamate dioxygenase ferredoxin reductase subunit [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945427, updated on 3-Dec-2024

    Summary

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    Official Symbol
    hcaD
    Official Full Name
    putative 3-phenylpropionate/cinnamate dioxygenase ferredoxin reductase subunit
    Primary source
    ECOCYC:G7336
    Locus tag
    b2542
    See related
    ASAP:ABE-0008363
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2539; hcaa4; phdA; yfhY
    Summary
    Hydrocinnamic acid is a synonym for 3-phenylpropionic acid. [More information is available at EcoGene: EG13460]. The 3-phenylpropionate dioxygenase component is the product of the hcaA1 and hcaA2 genes. [More information is available at EcoCyc: G7336].
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    Genomic context

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    Sequence:
    NC_000913.3 (2672047..2673249)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative 3-phenylpropionate/cinnamate dioxygenase subunit alpha Neighboring gene putative 3-phenylpropionate/cinnamate dioxygenase subunit beta Neighboring gene putative 3-phenylpropionate/cinnamate dioxygenase ferredoxin subunit Neighboring gene 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase Neighboring gene putative inner membrane protein Neighboring gene putative aldose 1-epimerase YphB

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. 3-phenylpropionate catabolism and the Escherichia coli oxidative stress response. Turlin E, et al. Res Microbiol, 2005 Apr. PMID 15808934
    2. Isolation and characterization of Escherichia coli mutants defective for phenylpropionate degradation. Burlingame RP, et al. J Bacteriol, 1986 Oct. PMID 3531186, Free PMC Article
    3. Flavoprotein disulfide reductases: advances in chemistry and function. Argyrou A, et al. Prog Nucleic Acid Res Mol Biol, 2004. PMID 15210329
    4. Characterization of the hca cluster encoding the dioxygenolytic pathway for initial catabolism of 3-phenylpropionic acid in Escherichia coli K-12. Díaz E, et al. J Bacteriol, 1998 Jun. PMID 9603882, Free PMC Article
    5. The binary protein-protein interaction landscape of Escherichia coli. Rajagopala SV, et al. Nat Biotechnol, 2014 Mar. PMID 24561554, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 3-phenylpropionate dioxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ferredoxin-NAD+ reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on NAD(P)H IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in 3-phenylpropionate catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within 3-phenylpropionate catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in 3-phenylpropionate catabolic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of 3-phenylpropionate dioxygenase complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    putative 3-phenylpropionate/cinnamate dioxygenase ferredoxin reductase subunit
    NP_417037.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2672047..2673249
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417037.1 putative 3-phenylpropionate/cinnamate dioxygenase ferredoxin reductase subunit [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417037.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376WZD0
      Conserved Domains (1) summary
      PRK09754
      Location:1 → 396
      PRK09754; phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional
    Nucleotide Protein
    Heading Accession and Version

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