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    yqjA DedA family protein YqjA [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947643, updated on 3-Dec-2024

    Summary

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    Official Symbol
    yqjA
    Official Full Name
    DedA family protein YqjA
    Primary source
    ECOCYC:G7609
    Locus tag
    b3095
    See related
    ASAP:ABE-0010181
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ecfL; ECK3086
    Summary
    A yqjA yghB double mutant has a membrane defect causing a cell division defect at low temperatures and an osmoremedial growth defect at elevated temperatures (Thomkins, 2008). [More information is available at EcoGene: EG12740]. YqjA is a member of the DedA family of inner membrane proteins . [More information is available at EcoCyc: G7609].
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    Genomic context

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    Sequence:
    NC_000913.3 (3247773..3248435)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional repressor ExuR Neighboring gene protein YqiM Neighboring gene modulator protein MzrA Neighboring gene DUF1090 domain-containing protein YqjC

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Topological analysis of a bacterial DedA protein associated with alkaline tolerance and antimicrobial resistance. Scarsbrook HL, et al. Microbiology (Reading), 2021 Dec. PMID 34914576
    2. Cpx-dependent expression of YqjA requires cations at elevated pH. Kumar S, et al. FEMS Microbiol Lett, 2017 Jul 3. PMID 28591809
    3. Identification of essential arginine residues of Escherichia coli DedA/Tvp38 family membrane proteins YqjA and YghB. Kumar S, et al. FEMS Microbiol Lett, 2016 Jul. PMID 27190159
    4. Inefficient Tat-dependent export of periplasmic amidases in an Escherichia coli strain with mutations in two DedA family genes. Sikdar R, et al. J Bacteriol, 2010 Feb. PMID 19880597, Free PMC Article
    5. Transcriptional response of Escherichia coli to external copper. Yamamoto K, et al. Mol Microbiol, 2005 Apr. PMID 15773991

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Topological analysis of a bacterial DedA protein associated with alkaline tolerance and antimicrobial resistance.
      Title: Topological analysis of a bacterial DedA protein associated with alkaline tolerance and antimicrobial resistance.
    2. study found that yqjA promoter activity was highest at alkaline pH. Increased activity of the yqjA promoter required both the transcriptional regulator CpxR, in agreement with previous results, and sodium or potassium salts at alkaline pH.
      Title: Cpx-dependent expression of YqjA requires cations at elevated pH.
    3. discovery of 2 conserved predicted membrane-embedded arginines (R130 and R136) that are critical for function in both YqjA and YghB; lysine can substitute for arginine at position R130 indicating a charge dependence at this position, but could not substitute at R136; study provides mechanistic insight into YqjA and YghB and supports the hypothesis that they function as membrane transporters
      Title: Identification of essential arginine residues of Escherichia coli DedA/Tvp38 family membrane proteins YqjA and YghB.
    4. Periplasmic amidases AmiC and AmiA, secreted by the twin arginine transport (Tat) pathway, are localized to the cytoplasm in Escherichia coli YqjA and YghB double mutant cells.
      Title: Inefficient Tat-dependent export of periplasmic amidases in an Escherichia coli strain with mutations in two DedA family genes.
    5. Data show that it is likely that YqjA play critical roles in membrane biology that are essential for completion of cell division in E. coli.
      Title: Temperature sensitivity and cell division defects in an Escherichia coli strain with mutations in yghB and yqjA, encoding related and conserved inner membrane proteins.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables transmembrane transporter activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within FtsZ-dependent cytokinesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within response to xenobiotic stimulus EXP
    Inferred from Experiment
    more info
    		 PubMed 
    acts_upstream_of_or_within transmembrane transport EXP
    Inferred from Experiment
    more info
    		 PubMed 
    acts_upstream_of_or_within transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DedA family protein YqjA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3247773..3248435
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417566.1 DedA family protein YqjA [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417566.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376FW85, A0A376JTT7
      Conserved Domains (1) summary
      COG0586
      Location:14 → 219
      DedA; Uncharacterized membrane protein DedA, SNARE-associated domain [Function unknown]
    Nucleotide Protein
    Heading Accession and Version

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