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    xylR DNA-binding transcriptional dual regulator XylR [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948086, updated on 3-Dec-2024

    Summary

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    Official Symbol
    xylR
    Official Full Name
    DNA-binding transcriptional dual regulator XylR
    Primary source
    ECOCYC:EG20253
    Locus tag
    b3569
    See related
    ASAP:ABE-0011652
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3558
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    Genomic context

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    Sequence:
    NC_000913.3 (3734979..3736157)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene xylose ABC transporter periplasmic binding protein Neighboring gene xylose ABC transporter ATP binding subunit Neighboring gene xylose ABC transporter membrane subunit Neighboring gene putative glycoside hydrolase Bax Neighboring gene putative translational regulatory protein BaxL Neighboring gene alpha-amylase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Availability of the Molecular Switch XylR Controls Phenotypic Heterogeneity and Lag Duration during Escherichia coli Adaptation from Glucose to Xylose. Barthe M, et al. mBio, 2020 Dec 22. PMID 33443125, Free PMC Article
    2. Experimental evolution reveals an effective avenue to release catabolite repression via mutations in XylR. Sievert C, et al. Proc Natl Acad Sci U S A, 2017 Jul 11. PMID 28655843, Free PMC Article
    3. AraC-XylS database: a family of positive transcriptional regulators in bacteria. Tobes R, et al. Nucleic Acids Res, 2002 Jan 1. PMID 11752325, Free PMC Article
    4. Computational analysis of the transcriptional regulation of pentose utilization systems in the gamma subdivision of Proteobacteria. Laikova ON, et al. FEMS Microbiol Lett, 2001 Dec 18. PMID 11750821
    5. A Col E1 hybrid plasmid containing Escherichia coli genes complementing d-xylose negative mutants of Escherichia coli and Salmonella typhimurium. Maleszka R, et al. Can J Biochem, 1982 Feb. PMID 6282416

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Availability of the Molecular Switch XylR Controls Phenotypic Heterogeneity and Lag Duration during Escherichia coli Adaptation from Glucose to Xylose.
      Title: Availability of the Molecular Switch XylR Controls Phenotypic Heterogeneity and Lag Duration during Escherichia coli Adaptation from Glucose to Xylose.
    2. two amino acid substitutions in XylR enhance xylose utilization and release glucose-induced repression in different E. coli hosts, including wild type, suggesting its potential wide application in industrial E. coli biocatalysts
      Title: Experimental evolution reveals an effective avenue to release catabolite repression via mutations in XylR.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription cis-regulatory region binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DNA-binding transcriptional dual regulator XylR

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3734979..3736157
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418026.1 DNA-binding transcriptional dual regulator XylR [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418026.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A3K1A2I0, A0A895NW80, A0A8S7NSB4, A0A8S7T787
      Conserved Domains (2) summary
      smart00342
      Location:301 → 384
      HTH_ARAC; helix_turn_helix, arabinose operon control protein
      cd01543
      Location:7 → 277
      PBP1_XylR; ligand-binding domain of DNA transcription repressor specific for xylose (XylR)
    Nucleotide Protein
    Heading Accession and Version

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