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    cytR DNA-binding transcriptional repressor CytR [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948427, updated on 17-Dec-2024

    Summary

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    Official Symbol
    cytR
    Official Full Name
    DNA-binding transcriptional repressor CytR
    Primary source
    ECOCYC:EG10200
    Locus tag
    b3934
    See related
    ASAP:ABE-0012853
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3926
    Summary
    This protein negatively controls the expression of the transcription units that encode the proteins and enzymes required for the transport (nupC, nupG, and tsx) and the utilization of nucleosides (deoCABD, udp, and cdd). [More information is available at EcoCyc: EG10200].
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    Genomic context

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    Sequence:
    NC_000913.3 (4123431..4124456, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene peptidase component of the HslVU protease Neighboring gene cell division protein FtsN Neighboring gene primosomal protein N' Neighboring gene 50S ribosomal subunit protein L31

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. [Mutational analysis of the CytR protein binding site within the regulatory region of Escherichia coli udp gene]. Domakova EV, et al. Genetika, 1999 Feb. PMID 10495936
    2. CytR/cAMP-CRP nucleoprotein formation in E. coli: the CytR repressor binds its operator as a stable dimer in a ternary complex with cAMP-CRP. Kristensen HH, et al. J Mol Biol, 1996 Jul 12. PMID 8764393
    3. Allosteric mechanism of induction of CytR-regulated gene expression. Cytr repressor-cytidine interaction. Barbier CS, et al. J Biol Chem, 1997 Jul 4. PMID 9202008
    4. DNA-binding characteristics of the Escherichia coli CytR regulator: a relaxed spacing requirement between operator half-sites is provided by a flexible, unstructured interdomain linker. Jørgensen CI, et al. Mol Microbiol, 1998 Jan. PMID 9466254
    5. Nucleotide sequence of the CytR regulatory gene of E. coli K-12. Valentin-Hansen P, et al. Nucleic Acids Res, 1986 Mar 11. PMID 3515317, Free PMC Article

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CytR exhibits features of an electric potential sensor modulating its dimensions and landscape in a unique distance-dependent manner while binding target DNA.
      Title: Tunable order-disorder continuum in protein-DNA interactions.
    2. Results indicate that while CytR forms a well-ordered structure in solution, it is highly dynamic.
      Title: Flexibility and adaptability in binding of E. coli cytidine repressor to different operators suggests a role in differential gene regulation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables DNA binding EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription cis-regulatory region binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA-binding transcriptional repressor CytR

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4123431..4124456 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418369.1 DNA-binding transcriptional repressor CytR [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418369.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A0H2Z4W2, A0A1X3J9S6, A0A7I6H8E5
      Conserved Domains (1) summary
      PRK11041
      Location:33 → 341
      PRK11041; DNA-binding transcriptional regulator CytR; Provisional
    Nucleotide Protein
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