U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    gdx guanidinium exporter [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948671, updated on 3-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    gdx
    Official Full Name
    guanidinium exporter
    Primary source
    ECOCYC:EG11616
    Locus tag
    b4148
    See related
    ASAP:ABE-0013588
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK4144; sugE
    Summary
    SugE belongs to the SMR efflux pump family, DMT superfamily. [More information is available at EcoGene: EG11616]. SugE is a member of the SMR family of proton-dependent drug efflux transporters . [More information is available at EcoCyc: EG11616].
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Sequence:
    NC_000913.3 (4376875..4377192)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene entericidin A lipoprotein, antidote to entericidin B Neighboring gene bacteriolytic entericidin B lipoprotein Neighboring gene outer membrane lipoprotein Blc Neighboring gene beta-lactamase Neighboring gene fumarate reductase membrane protein FrdD

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Spectroscopic analysis of the intrinsic chromophores within small multidrug resistance protein SugE. Bay DC, et al. Biochim Biophys Acta, 2011 Sep. PMID 21600871
    2. Guanidinium export is the primal function of SMR family transporters. Kermani AA, et al. Proc Natl Acad Sci U S A, 2018 Mar 20. PMID 29507227, Free PMC Article
    3. A novel multicopy suppressor of a groEL mutation includes two nested open reading frames transcribed from different promoters. Greener T, et al. EMBO J, 1993 Mar. PMID 8096175, Free PMC Article
    4. Transcription attenuation: a highly conserved regulatory strategy used by bacteria. Merino E, et al. Trends Genet, 2005 May. PMID 15851059
    5. SMR proteins SugE and EmrE bind ligand with similar affinity and stoichiometry. Sikora CW, et al. Biochem Biophys Res Commun, 2005 Sep 16. PMID 16055085

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Spectroscopic analysis of the intrinsic chromophores within small multidrug resistance protein SugE
      Title: Spectroscopic analysis of the intrinsic chromophores within small multidrug resistance protein SugE.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables antiporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in xenobiotic detoxification by transmembrane export across the plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    guanidinium exporter

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4376875..4377192
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418572.4 guanidinium exporter [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418572.4

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376MPY8
      Conserved Domains (1) summary
      PRK11431
      Location:1 → 105
      PRK11431; quaternary ammonium compound efflux SMR transporter SugE
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.