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    mgtA Mg(2(+)) importing P-type ATPase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948778, updated on 17-Dec-2024

    Summary

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    Official Symbol
    mgtA
    Official Full Name
    Mg(2(+)) importing P-type ATPase
    Primary source
    ECOCYC:EG12525
    Locus tag
    b4242
    See related
    ASAP:ABE-0013883
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    atmA; corB; ECK4237; mgt; mtg
    Summary
    Mg(2+) stimulon-PhoPQ regulon, EvgAS-PhoPQ cascade enhanced-expression subset. [More information is available at EcoGene: EG12525]. MgtA is a P-type ATPase involved in the uptake of magnesium ion . [More information is available at EcoCyc: EG12525].
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    Genomic context

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    Sequence:
    NC_000913.3 (4467625..4470321)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional repressor TreR Neighboring gene leader peptide MgtL Neighboring gene enamine/imine deaminase, redox-regulated chaperone Neighboring gene aspartate carbamoyltransferase, PyrI subunit

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The magnesium transporter A is activated by cardiolipin and is highly sensitive to free magnesium in vitro. Subramani S, et al. Elife, 2016 Jan 18. PMID 26780187, Free PMC Article
    2. The structure of Mg-ATPase nucleotide-binding domain at 1.6 A resolution reveals a unique ATP-binding motif. Håkansson KO. Acta Crystallogr D Biol Crystallogr, 2009 Nov. PMID 19923713
    3. Magnesium transport in Salmonella typhimurium: 28Mg2+ transport by the CorA, MgtA, and MgtB systems. Snavely MD, et al. J Bacteriol, 1989 Sep. PMID 2670893, Free PMC Article
    4. Regulation of magnesium homeostasis in Salmonella: Mg(2+) targets the mgtA transcript for degradation by RNase E. Spinelli SV, et al. FEMS Microbiol Lett, 2008 Mar. PMID 18248433
    5. An RNA sensor for intracellular Mg(2+). Cromie MJ, et al. Cell, 2006 Apr 7. PMID 16615891

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These findings indicate that MgtA may act as a sensor as well as a transporter of Mg(2+).
      Title: The magnesium transporter A is activated by cardiolipin and is highly sensitive to free magnesium in vitro.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled monoatomic cation transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables P-type ion transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables P-type ion transporter activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables P-type magnesium transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables P-type magnesium transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to magnesium ion IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within magnesium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in magnesium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Mg(2(+)) importing P-type ATPase
    NP_418663.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4467625..4470321
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418663.1 Mg(2(+)) importing P-type ATPase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418663.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S7EKB8
      Conserved Domains (1) summary
      PRK10517
      Location:1 → 898
      PRK10517; magnesium-transporting P-type ATPase MgtA
    Nucleotide Protein
    Heading Accession and Version

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