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    ampD 1,6-anhydro-N-acetylmuramoyl-L-alanine amidase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948877, updated on 17-Dec-2024

    Summary

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    Official Symbol
    ampD
    Official Full Name
    1,6-anhydro-N-acetylmuramoyl-L-alanine amidase
    Primary source
    ECOCYC:EG10041
    Locus tag
    b0110
    See related
    ASAP:ABE-0000380
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0109
    Summary
    ampD is a member of the ampDE operon. [More information is available at EcoCyc: EG10041].
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    Genomic context

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    Sequence:
    NC_000913.3 (118733..119284)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene prepilin-type N-terminal cleavage/methylation domain-containing protein PpdD Neighboring gene quinolinate phosphoribosyltransferase (decarboxylating) Neighboring gene protein AmpE Neighboring gene aromatic amino acid:H(+) symporter AroP Neighboring gene DNA-binding transcriptional dual regulator PdhR

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Bacterial AmpD at the crossroads of peptidoglycan recycling and manifestation of antibiotic resistance. Lee M, et al. J Am Chem Soc, 2009 Jul 1. PMID 19496566, Free PMC Article
    2. Total synthesis of N-acetylglucosamine-1,6-anhydro-N-acetylmuramylpentapeptide and evaluation of its turnover by AmpD from Escherichia coli. Hesek D, et al. J Am Chem Soc, 2009 Apr 15. PMID 19309146, Free PMC Article
    3. Stress-induced beta-lactam antibiotic resistance mutation and sequences of stationary-phase mutations in the Escherichia coli chromosome. Petrosino JF, et al. J Bacteriol, 2009 Oct. PMID 19648247, Free PMC Article
    4. The negative regulator of beta-lactamase induction AmpD is a N-acetyl-anhydromuramyl-L-alanine amidase. Höltje JV, et al. FEMS Microbiol Lett, 1994 Sep 15. PMID 7958768
    5. Factors influencing gene expression and resistance for Gram-negative organisms expressing plasmid-encoded ampC genes of Enterobacter origin. Reisbig MD, et al. J Antimicrob Chemother, 2003 May. PMID 12697654

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables N-acetyl-anhydromuramoyl-L-alanine amidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables N-acetylmuramoyl-L-alanine amidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables N-acetylmuramoyl-L-alanine amidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell wall organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in peptidoglycan catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in peptidoglycan catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in peptidoglycan turnover IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in peptidoglycan turnover IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    1,6-anhydro-N-acetylmuramoyl-L-alanine amidase
    NP_414652.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      118733..119284
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414652.1 1,6-anhydro-N-acetylmuramoyl-L-alanine amidase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414652.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      Q14F42
      Conserved Domains (1) summary
      PRK11789
      Location:1 → 183
      PRK11789; 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD
    Nucleotide Protein
    Heading Accession and Version

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