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    dgt dGTP triphosphohydrolase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947177, updated on 3-Dec-2024

    Summary

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    Official Symbol
    dgt
    Official Full Name
    dGTP triphosphohydrolase
    Primary source
    ECOCYC:EG10225
    Locus tag
    b0160
    See related
    ASAP:ABE-0000548
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0159; optA
    Summary
    Deoxyguanosinetriphosphate triphosphohydrolase (dGTPase) is a unique nucleoside triphosphatase in that it hydrolyzes dGTP to deoxyguanosine and inorganic tripolyphosphate. [More information is available at EcoCyc: EG10225].
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    Genomic context

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    Sequence:
    NC_000913.3 (179237..180754)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene PF03458 family protein YadS Neighboring gene vitamin B12 ABC transporter periplasmic binding protein Neighboring gene 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Neighboring gene periplasmic serine endoprotease DegP Neighboring gene DNA-binding transcriptional activator CdaR

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. DNA binding properties of the deoxyguanosine triphosphate triphosphohydrolase of Escherichia coli. Wurgler SM, et al. J Biol Chem, 1993 Sep 25. PMID 8397198
    2. dGTP triphosphohydrolase, a unique enzyme confined to members of the family Enterobacteriaceae. Quirk S, et al. J Bacteriol, 1991 Nov. PMID 1657865, Free PMC Article
    3. The gene 1.2 protein of bacteriophage T7 interacts with the Escherichia coli dGTP triphosphohydrolase to form a GTP-binding protein. Nakai H, et al. J Biol Chem, 1990 Mar 15. PMID 2155228
    4. Location and molecular cloning of the structural gene for the deoxyguanosine triphosphate triphosphohydrolase of Escherichia coli. Quirk S, et al. Mol Microbiol, 1989 Oct. PMID 2559296
    5. A unique deoxyguanosine triphosphatase is responsible for the optA1 phenotype of Escherichia coli. Beauchamp BB, et al. Proc Natl Acad Sci U S A, 1988 Apr. PMID 2833745, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mechanism by which T7 bacteriophage protein Gp1.2 inhibits Escherichia coli dGTPase.
      Title: Mechanism by which T7 bacteriophage protein Gp1.2 inhibits Escherichia coli dGTPase.
    2. Ec-dGTPase residues at the end of the substrate-binding pocket mimic Watson-Crick interactions providing guanine base specificity.
      Title: The crystal structure of dGTPase reveals the molecular basis of dGTP selectivity.
    3. The enzyme is shown to be a hexameric structure containing regulatory DNA molecules.
      Title: Structure of Escherichia coli dGTP triphosphohydrolase: a hexameric enzyme with DNA effector molecules.
    4. our results suggest that the dgt-dependent pathway for deoxyribose-1-phosphate generation may operate under various cell conditions to provide deoxyribosyl donors.
      Title: The dgt gene of Escherichia coli facilitates thymine utilization in thymine-requiring strains.
    5. Data suggests that alterations of the dGTP pools as well as alterations in the level of some modified dNTP derivatives could affect the fidelity of in vivo DNA replication and, hence, account for the overall mutator effects.
      Title: A novel mutator of Escherichia coli carrying a defect in the dgt gene, encoding a dGTP triphosphohydrolase.
    6. N-terminus verified by Edman degradation on mature peptide
      Title: A unique deoxyguanosine triphosphatase is responsible for the optA1 phenotype of Escherichia coli.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables GTPase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cobalt ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables dGTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dGTPase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables dGTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables manganese ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables single-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in dGTP catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in dGTP catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within nucleobase-containing small molecule interconversion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within pyrimidine deoxyribonucleoside salvage IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dGTP triphosphohydrolase
    NP_414702.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      179237..180754
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414702.1 dGTP triphosphohydrolase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414702.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A7A6RVI6, A0A828PKA7
      Conserved Domains (1) summary
      PRK04926
      Location:1 → 504
      dgt; deoxyguanosinetriphosphate triphosphohydrolase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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