lpxB lipid A disaccharide synthase [Escherichia coli str. K-12 substr. MG1655] - Gene

Summary

Official Symbol: lpxB
Official Full Name: lipid A disaccharide synthase
Primary source: ECOCYC:EG10546
Locus tag: b0182
See related: ASAP:ABE-0000620
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage: Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as: ECK0181; pgsB
Summary: The lpxB1 mutation is E326K, the result of a change in codon 326 from GAA to AAA (C.R.H. [More information is available at EcoGene: EG10546]. Lipid A disaccharide synthase (LpxB) catalyzes the fifth step in lipid A biosynthesis. [More information is available at EcoCyc: EG10546].
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NC_000913.3 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Crystal structure of LpxB has been resolved.
Title: Crystal structure of lipid A disaccharide synthase LpxB from Escherichia coli.
N-terminus verified by Edman degradation on complete protein
Title: Purification and properties of lipid A disaccharide synthase of Escherichia coli.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IDA Inferred from Direct Assay more info	PubMed
enables lipid-A-disaccharide synthase activity	IDA Inferred from Direct Assay more info	PubMed
enables lipid-A-disaccharide synthase activity	IEA Inferred from Electronic Annotation more info
enables phospholipid binding	IBA Inferred from Biological aspect of Ancestor more info
enables phospholipid binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in lipid A biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in lipid A biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid A biosynthetic process	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within lipid A biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in extrinsic component of cytoplasmic side of plasma membrane	IC Inferred by Curator more info	PubMed
located_in extrinsic component of plasma membrane	IDA Inferred from Direct Assay more info	PubMed

NP_414724.1

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