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    ybhA pyridoxal phosphate/fructose-1,6-bisphosphate phosphatase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945372, updated on 3-Dec-2024

    Summary

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    Official Symbol
    ybhA
    Official Full Name
    pyridoxal phosphate/fructose-1,6-bisphosphate phosphatase
    Primary source
    ECOCYC:EG11239
    Locus tag
    b0766
    See related
    ASAP:ABE-0002607
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0755
    Summary
    HAD superfamily. [More information is available at EcoGene: EG11239]. YbhA is a promiscuous phosphatase belonging to the superfamily of haloacid dehalogenase (HAD)-like hydrolases. [More information is available at EcoCyc: EG11239].
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    Genomic context

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    Sequence:
    NC_000913.3 (797613..798431, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene molybdate ABC transporter periplasmic binding protein Neighboring gene molybdate ABC transporter membrane subunit Neighboring gene molybdate ABC transporter ATP binding subunit Neighboring gene 6-phosphogluconolactonase Neighboring gene putative DNA-binding transcriptional regulator YbhD

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of YbhA as the pyridoxal 5'-phosphate (PLP) phosphatase in Escherichia coli: Importance of PLP homeostasis on the bacterial growth. Sugimoto R, et al. J Gen Appl Microbiol, 2018 Jan 15. PMID 29187681
    2. Metabolomics approach for enzyme discovery. Saito N, et al. J Proteome Res, 2006 Aug. PMID 16889420
    3. Cloning and nucleotide sequence of the chlD locus. Johann S, et al. J Bacteriol, 1987 May. PMID 3553151, Free PMC Article
    4. Regulation of the molybdate transport operon, modABCD, of Escherichia coli in response to molybdate availability. Rech S, et al. J Bacteriol, 1995 Feb. PMID 7860583, Free PMC Article
    5. Structural and biochemical characterization of the type II fructose-1,6-bisphosphatase GlpX from Escherichia coli. Brown G, et al. J Biol Chem, 2009 Feb 6. PMID 19073594, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphotransferase activity, alcohol group as acceptor IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables pyridoxal phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables pyridoxal phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pyridoxal phosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables sugar-phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within pyridoxal phosphate catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    pyridoxal phosphate/fructose-1,6-bisphosphate phosphatase
    NP_415287.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      797613..798431 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415287.1 pyridoxal phosphate/fructose-1,6-bisphosphate phosphatase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415287.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S7TPV3
      Conserved Domains (1) summary
      PRK10530
      Location:1 → 272
      PRK10530; pyridoxal phosphate (PLP) phosphatase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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