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    fabF 3-oxoacyl-[acyl carrier protein] synthase 2 [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946665, updated on 3-Dec-2024

    Summary

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    Official Symbol
    fabF
    Official Full Name
    3-oxoacyl-[acyl carrier protein] synthase 2
    Primary source
    ECOCYC:EG12606
    Locus tag
    b1095
    See related
    ASAP:ABE-0003705
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    cvc; ECK1081; fabJ; vtr; vtrB
    Summary
    There are three -ketoacyl-ACP synthases (KAS) in Escherichia coli: |FRAME: [More information is available at EcoCyc: EG12606].
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    Genomic context

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    Sequence:
    NC_000913.3 (1151939..1153180)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene 3-oxoacyl-[acyl-carrier-protein] reductase FabG Neighboring gene acyl carrier protein Neighboring gene aminodeoxychorismate lyase Neighboring gene endolytic murein transglycosylase Neighboring gene Tmk

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Multiple forms of beta-ketoacyl-acyl carrier protein synthetase in Escherichia coli. D'Agnolo G, et al. J Biol Chem, 1975 Jul 25. PMID 237914
    2. Mutant of Escherichia coli deficient in the synthesis of cis-vaccenic acid. Gelmann EP, et al. J Bacteriol, 1972 Oct. PMID 4562402, Free PMC Article
    3. The putative fabJ gene of Escherichia coli fatty acid synthesis is the fabF gene. Magnuson K, et al. J Bacteriol, 1995 Jun. PMID 7768872, Free PMC Article
    4. Structure of the complex between the antibiotic cerulenin and its target, beta-ketoacyl-acyl carrier protein synthase. Moche M, et al. J Biol Chem, 1999 Mar 5. PMID 10037680
    5. Assessment of Rhodopseudomonas sphaeroides chromatophore membrane asymmetry through bilateral antiserum adsorption studies. Collins ML, et al. J Bacteriol, 1980 Jul. PMID 6967482, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These data taken together support a gating mechanism that regulates acyl-ACP binding and substrate delivery to the beta-ketoacyl-acyl carrier protein (ACP) synthases (FabF and FabB) active site.
      Title: Gating mechanism of elongating β-ketoacyl-ACP synthases.
    2. N-terminus verified by Edman degradation on mature peptide
      Title: The fabJ-encoded beta-ketoacyl-[acyl carrier protein] synthase IV from Escherichia coli is sensitive to cerulenin and specific for short-chain substrates.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 3-oxoacyl-[acyl-carrier-protein] synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3-oxoacyl-[acyl-carrier-protein] synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 3-oxoacyl-[acyl-carrier-protein] synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in fatty acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within fatty acid elongation, saturated fatty acid IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within monounsaturated fatty acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to cold IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in small molecule metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    3-oxoacyl-[acyl carrier protein] synthase 2
    NP_415613.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1151939..1153180
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415613.1 3-oxoacyl-[acyl carrier protein] synthase 2 [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415613.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A5B9AKE4
      Conserved Domains (1) summary
      PRK07314
      Location:3 → 413
      PRK07314; beta-ketoacyl-ACP synthase II
    Nucleotide Protein
    Heading Accession and Version

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