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    chaC glutathione-specific gamma-glutamylcyclotransferase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945793, updated on 3-Dec-2024

    Summary

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    Official Symbol
    chaC
    Official Full Name
    glutathione-specific gamma-glutamylcyclotransferase
    Primary source
    ECOCYC:EG12403
    Locus tag
    b1218
    See related
    ASAP:ABE-0004089
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1212
    Summary
    A chaC mutant shows a defect in swarming motility, but no significant defect in swimming motility . [More information is available at EcoCyc: EG12403].
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    Genomic context

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    Sequence:
    NC_000913.3 (1272507..1273202)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene Na(+)/K(+):H(+) antiporter ChaA Neighboring gene putative cation transport regulator ChaB Neighboring gene DsrE/F sulfur relay family protein YchN Neighboring gene putative invasin YchO

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning and characterization of a putative Ca2+/H+ antiporter gene from Escherichia coli upon functional complementation of Na+/H+ antiporter-deficient strains by the overexpressed gene. Ivey DM, et al. J Biol Chem, 1993 May 25. PMID 8496184
    2. Metabolic context and possible physiological themes of sigma(54)-dependent genes in Escherichia coli. Reitzer L, et al. Microbiol Mol Biol Rev, 2001 Sep. PMID 11528004, Free PMC Article
    3. ChaC2, an Enzyme for Slow Turnover of Cytosolic Glutathione. Kaur A, et al. J Biol Chem, 2017 Jan 13. PMID 27913623, Free PMC Article
    4. A comprehensive library of fluorescent transcriptional reporters for Escherichia coli. Zaslaver A, et al. Nat Methods, 2006 Aug. PMID 16862137
    5. Mammalian proapoptotic factor ChaC1 and its homologues function as γ-glutamyl cyclotransferases acting specifically on glutathione. Kumar A, et al. EMBO Rep, 2012 Dec. PMID 23070364, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables gamma-glutamylcyclotransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glutathione specific gamma-glutamylcyclotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione specific gamma-glutamylcyclotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within glutathione catabolic process EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in glutathione catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glutathione catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    glutathione-specific gamma-glutamylcyclotransferase
    NP_415736.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1272507..1273202
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415736.2 glutathione-specific gamma-glutamylcyclotransferase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415736.2

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A792HRH6
      Conserved Domains (1) summary
      COG3703
      Location:34 → 224
      ChaC; Cation transport regulator ChaC [Inorganic ion transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version

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