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    mppA murein tripeptide ABC transporter periplasmic binding protein [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945951, updated on 3-Dec-2024

    Summary

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    Official Symbol
    mppA
    Official Full Name
    murein tripeptide ABC transporter periplasmic binding protein
    Primary source
    ECOCYC:G6665
    Locus tag
    b1329
    See related
    ASAP:ABE-0004460
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1326; ynaH
    Summary
    Escherichia coli does not normally use exogeneous heme, but heme can be utilized if a foreign OM heme receptor is expressed in Escherichia coli; heme and tripeptides compete for the same binding site; DppA is an alternative heme periplasmic binding protein; MppA or DppA is required for the uptake of 5-aminolevulinic acid (Letoffe, 2006). [More information is available at EcoGene: EG13376]. MppA is the periplasmic binding component of the murein tripeptide ABC transporter . [More information is available at EcoCyc: G6665].
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    Genomic context

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    Sequence:
    NC_000913.3 (1393227..1394840)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein YmjD Neighboring gene putative hydrolase YcjY Neighboring gene DNA-binding transcriptional repressor PgrR Neighboring gene small conductance mechanosensitive channel YnaI Neighboring gene IS5 family transposase and trans-activator

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Compensating stereochemical changes allow murein tripeptide to be accommodated in a conventional peptide-binding protein. Maqbool A, et al. J Biol Chem, 2011 Sep 9. PMID 21705338, Free PMC Article
    2. The periplasmic murein peptide-binding protein MppA is a negative regulator of multiple antibiotic resistance in Escherichia coli. Li H, et al. J Bacteriol, 1999 Aug. PMID 10438753, Free PMC Article
    3. Membrane topology of the integral membrane components, OppB and OppC, of the oligopeptide permease of Salmonella typhimurium. Pearce SR, et al. Mol Microbiol, 1992 Jan. PMID 1738314
    4. Molecular characterization of the oligopeptide permease of Salmonella typhimurium. Hiles ID, et al. J Mol Biol, 1987 May 5. PMID 2821267
    5. Binding specificity of the periplasmic oligopeptide-binding protein from Escherichia coli. Guyer CA, et al. J Bacteriol, 1986 Nov. PMID 3536860, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on mature peptide
      Title: MppA, a periplasmic binding protein essential for import of the bacterial cell wall peptide L-alanyl-gamma-D-glutamyl-meso-diaminopimelate.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables oligopeptide binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables peptide transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in dipeptide transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in heme transmembrane transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in peptide transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in peptide transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within peptidoglycan-associated peptide transport EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tripeptide import across plasma membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within tripeptide transport EXP
    Inferred from Experiment
    more info
    		 PubMed 
    acts_upstream_of_or_within tripeptide transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of ATP-binding cassette (ABC) transporter complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in outer membrane-bounded periplasmic space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in outer membrane-bounded periplasmic space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in outer membrane-bounded periplasmic space IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in periplasmic space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in periplasmic space IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    murein tripeptide ABC transporter periplasmic binding protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1393227..1394840
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415845.2 murein tripeptide ABC transporter periplasmic binding protein [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415845.2

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376WZ00, A0A8S7TT40
      Conserved Domains (1) summary
      cd08504
      Location:35 → 534
      PBP2_OppA; The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold
    Nucleotide Protein
    Heading Accession and Version

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