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    pheS phenylalanine--tRNA ligase subunit alpha [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946223, updated on 17-Dec-2024

    Summary

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    Official Symbol
    pheS
    Official Full Name
    phenylalanine--tRNA ligase subunit alpha
    Primary source
    ECOCYC:EG10709
    Locus tag
    b1714
    See related
    ASAP:ABE-0005722
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1712; phe-act
    Summary
    HT_Cmplx7_Cyt: [More information is available at EcoGene: EG10709]. The subunit of PheRS contains the phenylalanine binding site within the conserved motif 2 and motif 3 of the protein . [More information is available at EcoCyc: EG10709].
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    Genomic context

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    Sequence:
    NC_000913.3 (1797959..1798942, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene integration host factor subunit alpha Neighboring gene phenylalanine--tRNA ligase subunit beta Neighboring gene pheST-ihfA operon leader peptide Neighboring gene 50S ribosomal subunit protein L20

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. G673 could be a novel mutational hot spot for intragenic suppressors of pheS5 lesion in Escherichia coli. Ponmani T, et al. Microbiologyopen, 2014 Jun. PMID 24811065, Free PMC Article
    2. PROTEIN AND NUCLEIC ACID SYNTHESIS IN TWO MUTANTS OF ESCHERICHIA COLI WITH TEMPERATURE-SENSITIVE AMINOACYL RIBONUCLEIC ACID SYNTHETASES. EIDLIC L, et al. J Bacteriol, 1965 Mar. PMID 14273649, Free PMC Article
    3. Impaired affinity for phenylalanine in Escherichia coli phenylalanyl-tRNA synthetase mutant caused by Gly-to-Asp exchange in motif 2 of class II tRNA synthetases. Kast P, et al. FEBS Lett, 1991 Nov 18. PMID 1959653
    4. Amino acid substrate specificity of Escherichia coli phenylalanyl-tRNA synthetase altered by distinct mutations. Kast P, et al. J Mol Biol, 1991 Nov 5. PMID 1942071
    5. Altered alpha subunits in phenylalanyl-tRNA synthetases from p-fluorophenylalanine-resistant strains of Escherichis coli. Hennecke H, et al. Eur J Biochem, 1975 Jul 1. PMID 1104359

    See all (89) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aminoacyl-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phenylalanine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phenylalanine-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables tRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in phenylalanyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phenylalanyl-tRNA aminoacylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phenylalanyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phenylalanyl-tRNA aminoacylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of phenylalanine-tRNA ligase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of phenylalanine-tRNA ligase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    phenylalanine--tRNA ligase subunit alpha
    NP_416229.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1797959..1798942 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416229.1 phenylalanine--tRNA ligase subunit alpha [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416229.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A6C9MB86
      Conserved Domains (1) summary
      PRK00488
      Location:1 → 326
      pheS; phenylalanyl-tRNA synthetase subunit alpha; Validated
    Nucleotide Protein
    Heading Accession and Version

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