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    cho excinuclease Cho [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948996, updated on 3-Dec-2024

    Summary

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    Official Symbol
    cho
    Official Full Name
    excinuclease Cho
    Primary source
    ECOCYC:G6937
    Locus tag
    b1741
    See related
    ASAP:ABE-0005807
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1739; ydjQ
    Summary
    Homologous to N-terminal domain of UvrC. [More information is available at EcoGene: EG13993]. Cho is a DNA repair endonuclease that acts together with UvrC in incision repair of some DNA lesions . [More information is available at EcoCyc: G6937].
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    Genomic context

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    Sequence:
    NC_000913.3 (1823515..1824402)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene osmotically-inducible lipoprotein OsmE Neighboring gene NH3-dependent NAD(+) synthetase Neighboring gene HutD family protein Ves Neighboring gene ATP-independent periplasmic chaperone Neighboring gene succinylglutamate desuccinylase Neighboring gene N-succinylarginine dihydrolase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cho Endonuclease Functions during DNA Interstrand Cross-Link Repair in Escherichia coli. Perera AV, et al. J Bacteriol, 2016 Nov 15. PMID 27573016, Free PMC Article
    2. A cut above: discovery of an alternative excision repair pathway in bacteria. Van Houten B, et al. Proc Natl Acad Sci U S A, 2002 Mar 5. PMID 11880612, Free PMC Article
    3. Cho, a second endonuclease involved in Escherichia coli nucleotide excision repair. Moolenaar GF, et al. Proc Natl Acad Sci U S A, 2002 Feb 5. PMID 11818552, Free PMC Article
    4. Identification of high affinity binding sites for LexA which define new DNA damage-inducible genes in Escherichia coli. Lewis LK, et al. J Mol Biol, 1994 Aug 26. PMID 8057377
    5. Genetic analysis of repair and damage tolerance mechanisms for DNA-protein cross-links in Escherichia coli. Salem AM, et al. J Bacteriol, 2009 Sep. PMID 19617358, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables DNA endonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA damage response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within DNA damage response IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in SOS response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within SOS response IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in nucleotide-excision repair IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in nucleotide-excision repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of excinuclease repair complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    excinuclease Cho

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1823515..1824402
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416255.1 excinuclease Cho [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416255.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A7H9S8J1
      Conserved Domains (1) summary
      PRK10545
      Location:1 → 286
      PRK10545; excinuclease Cho
    Nucleotide Protein
    Heading Accession and Version

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