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    mdtA multidrug efflux pump membrane fusion protein MdtA [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946604, updated on 3-Dec-2024

    Summary

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    Official Symbol
    mdtA
    Official Full Name
    multidrug efflux pump membrane fusion protein MdtA
    Primary source
    ECOCYC:G7113
    Locus tag
    b2074
    See related
    ASAP:ABE-0006872
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2070; yegM
    Summary
    mdtABC overexpression confers resistance to deoxycholate and novobiocin. [More information is available at EcoGene: EG14056]. [More information is available at EcoCyc: G7113].
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    Genomic context

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    Sequence:
    NC_000913.3 (2154016..2155263)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene toxic peptide IbsA Neighboring gene ncRNA Neighboring gene putative toxic peptide IbsB Neighboring gene multidrug efflux pump RND permease subunit MdtB Neighboring gene multidrug efflux pump RND permease subunit MdtC

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Multidrug efflux pump MdtBC of Escherichia coli is active only as a B2C heterotrimer. Kim HS, et al. J Bacteriol, 2010 Mar. PMID 20038594, Free PMC Article
    2. AcrB, AcrD, and MdtABC multidrug efflux systems are involved in enterobactin export in Escherichia coli. Horiyama T, et al. PLoS One, 2014. PMID 25259870, Free PMC Article
    3. The baeSR two-component regulatory system activates transcription of the yegMNOB (mdtABCD) transporter gene cluster in Escherichia coli and increases its resistance to novobiocin and deoxycholate. Baranova N, et al. J Bacteriol, 2002 Aug. PMID 12107134, Free PMC Article
    4. Indole induces the expression of multidrug exporter genes in Escherichia coli. Hirakawa H, et al. Mol Microbiol, 2005 Feb. PMID 15686558
    5. Beta-lactam resistance modulated by the overexpression of response regulators of two-component signal transduction systems in Escherichia coli. Hirakawa H, et al. J Antimicrob Chemother, 2003 Oct. PMID 12951338

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables bile acid transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables efflux transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within bile acid and bile salt transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in xenobiotic detoxification by transmembrane export across the cell outer membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within xenobiotic transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of efflux pump complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of efflux pump complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in periplasmic side of plasma membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    multidrug efflux pump membrane fusion protein MdtA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2154016..2155263
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416578.2 multidrug efflux pump membrane fusion protein MdtA [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416578.2

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S7FD40
      Conserved Domains (1) summary
      PRK11556
      Location:1 → 415
      PRK11556; MdtA/MuxA family multidrug efflux RND transporter periplasmic adaptor subunit
    Nucleotide Protein
    Heading Accession and Version

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