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    ygaM DUF883 domain-containing protein YgaM [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947157, updated on 17-Dec-2024

    Summary

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    Official Symbol
    ygaM
    Official Full Name
    DUF883 domain-containing protein YgaM
    Primary source
    ECOCYC:G7400
    Locus tag
    b2672
    See related
    ASAP:ABE-0008799
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2666
    Summary
    ygaM is upregulated by sodium salicylate, which is also known to cause the induction of the marRAB regulon resulting in resistance to oxidative agents and antibiotics . ygaM was also shown to be induced at the transition to stationary phase, upon NaCl shock, and upon acid shock in a rpoS+ strain compared to a rpoS mutant, and is therefore believed to be controlled by the general stress response master regulator, S . ygaM was shown to cluster with osmoprotectant genes having supercoiling-dependent transcription . ygaM is among the 25 genes most susceptible to phage insertion at mid-log phase growth, which was shown to prefer regions of low transcription . [More information is available at EcoCyc: G7400].
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    Genomic context

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    Sequence:
    NC_000913.3 (2800146..2800475)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene L-alanine exporter Neighboring gene DUF2002 domain-containing protein YgaC Neighboring gene glutaredoxin-like protein NrdH Neighboring gene dimanganese-tyrosyl radical cofactor maintenance flavodoxin NrdI Neighboring gene ribonucleoside-diphosphate reductase 2 subunit alpha

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Microarray analysis of transposition targets in Escherichia coli: the impact of transcription. Manna D, et al. Proc Natl Acad Sci U S A, 2004 Jun 29. PMID 15210965, Free PMC Article
    2. A microarray-based antibiotic screen identifies a regulatory role for supercoiling in the osmotic stress response of Escherichia coli. Cheung KJ, et al. Genome Res, 2003 Feb. PMID 12566398, Free PMC Article
    3. Genome-wide transcriptional profiling of the Escherichia coli responses to superoxide stress and sodium salicylate. Pomposiello PJ, et al. J Bacteriol, 2001 Jul. PMID 11395452, Free PMC Article
    4. Genome-wide analysis of the general stress response network in Escherichia coli: sigmaS-dependent genes, promoters, and sigma factor selectivity. Weber H, et al. J Bacteriol, 2005 Mar. PMID 15716429, Free PMC Article
    5. Membranome: a database for proteome-wide analysis of single-pass membrane proteins. Lomize AL, et al. Nucleic Acids Res, 2017 Jan 4. PMID 27510400, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ribosome binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DUF883 domain-containing protein YgaM

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2800146..2800475
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417158.4 DUF883 domain-containing protein YgaM [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417158.4

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A2X1MT32
      Conserved Domains (1) summary
      PRK10132
      Location:1 → 108
      PRK10132; hypothetical protein; Provisional
    Nucleotide Protein
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