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    hycB formate hydrogenlyase subunit HycB [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948002, updated on 3-Dec-2024

    Summary

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    Official Symbol
    hycB
    Official Full Name
    formate hydrogenlyase subunit HycB
    Primary source
    ECOCYC:EG10475
    Locus tag
    b2724
    See related
    ASAP:ABE-0008950
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2719; hevB
    Summary
    FhlA regulon. [More information is available at EcoGene: EG10475]. HycB is thought to code for a subunit of hydrogenase 3, a peptide of the [4Fe-4S] ferredoxin type, which functions as an intermediate electron carrier protein between hydrogenase 3 and formate dehydrogenase . [More information is available at EcoCyc: EG10475].
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    Genomic context

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    Sequence:
    NC_000913.3 (2849238..2849849, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene formate hydrogenlyase subunit HycE Neighboring gene formate hydrogenlyase subunit HycD Neighboring gene formate hydrogenlyase subunit HycC Neighboring gene regulator of the transcriptional regulator FhlA Neighboring gene hydrogenase 3 nickel incorporation protein HypA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mechanism of regulation of the formate-hydrogenlyase pathway by oxygen, nitrate, and pH: definition of the formate regulon. Rossmann R, et al. Mol Microbiol, 1991 Nov. PMID 1779767
    2. Microbial reduction of technetium by Escherichia coli and Desulfovibrio desulfuricans: enhancement via the use of high-activity strains and effect of process parameters. Lloyd JR, et al. Biotechnol Bioeng, 1999. PMID 10567070
    3. Reduction and removal of heptavalent technetium from solution by Escherichia coli. Lloyd JR, et al. J Bacteriol, 1997 Mar. PMID 9068649, Free PMC Article
    4. [K+-dependent enzyme activity of H+-ATPase in the E. coli membrane]. Trchunian AA, et al. Biofizika, 1991 Jan-Feb. PMID 1830224
    5. Relationship between formate hydrogen lyase and proton-potassium pump under heterolactic fermentation in Escherichia coli: functional multienzyme associations in the cell membrane. Trchounian AA, et al. Membr Cell Biol, 2000. PMID 10926369

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 4 iron, 4 sulfur cluster binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in anaerobic electron transport chain IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in anaerobic respiration IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in formate oxidation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in glucose catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of formate dehydrogenase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    formate hydrogenlyase subunit HycB
    NP_417204.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2849238..2849849 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417204.1 formate hydrogenlyase subunit HycB [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417204.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376D3R9, A0A376MGR1
      Conserved Domains (1) summary
      cd10554
      Location:4 → 167
      HycB_like; HycB, HydN and similar proteins
    Nucleotide Protein
    Heading Accession and Version

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