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    galP galactose:H(+) symporter [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947434, updated on 3-Dec-2024

    Summary

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    Official Symbol
    galP
    Official Full Name
    galactose:H(+) symporter
    Primary source
    ECOCYC:EG12148
    Locus tag
    b2943
    See related
    ASAP:ABE-0009654
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2938; Pgal
    Summary
    Major Facilitator Superfamily (MFS). [More information is available at EcoGene: EG12148]. GalP is a member of the Major Facilitator Superfamily (MFS) of transporters and is one of two, along with MglABC, major routes for galactose transport into Escherichia coli . [More information is available at EcoCyc: EG12148].
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    Genomic context

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    Sequence:
    NC_000913.3 (3088284..3089678)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene protein YqgC Neighboring gene DUF2684 domain-containing protein YqgD Neighboring gene methionine adenosyltransferase Neighboring gene protein YggI Neighboring gene DNA-specific endonuclease I

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The kinetics and thermodynamics of the binding of cytochalasin B to sugar transporters. Walmsley AR, et al. Eur J Biochem, 1994 Apr 1. PMID 8168538
    2. Specific spin labelling of the sugar-H(+) symporter, GalP, in cell membranes of Escherichia coli: site mobility and overall rotational diffusion of the protein. Marsh D, et al. Biochim Biophys Acta, 2001 Feb 9. PMID 11342180
    3. Cysteine residues in the D-galactose-H+ symport protein of Escherichia coli: effects of mutagenesis on transport, reaction with N-ethylmaleimide and antibiotic binding. McDonald TP, et al. Biochem J, 2001 Feb 1. PMID 11171069, Free PMC Article
    4. Selective NMR observation of inhibitor and sugar binding to the galactose-H(+) symport protein GalP, of Escherichia coli. Appleyard AN, et al. Biochim Biophys Acta, 2000 Dec 20. PMID 11118517
    5. Expression of prokaryotic membrane transport proteins in Escherichia coli. Ward A, et al. Biochem Soc Trans, 1999 Dec. PMID 10830123

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. galactose-binding protein
      Title: Kinetic analysis of the inhibition of the drug efflux protein AcrB using surface plasmon resonance.
    2. Unfolding free energy of a two-domain transmembrane sugar transport protein, GalP.
      Title: Unfolding free energy of a two-domain transmembrane sugar transport protein.
    3. Each monomer in the trimer forms its own channel, but an additional cavity (10 approximately 15 A in diameter) is apparent at the 3-fold axis of the oligomer.
      Title: The prototypical H+/galactose symporter GalP assembles into functional trimers.
    4. galP is repressed by a combination of NagC, GalR and GalS.
      Title: Repression of galP, the galactose transporter in Escherichia coli, requires the specific regulator of N-acetylglucosamine metabolism.
    5. effects of the galP mutations W56F, W239F, R316W, T336Y and W434F on glucose binding
      Title: Relative substrate affinities of wild-type and mutant forms of the Escherichia coli sugar transporter GalP determined by solid-state NMR.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables galactose:proton symporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within galactose transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    galactose:H(+) symporter

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3088284..3089678
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417418.1 galactose:H(+) symporter [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417418.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A5B9ASI2, A0A6M9X6J5, A0A8S7TSV1
      Conserved Domains (1) summary
      TIGR00879
      Location:9 → 447
      SP; MFS transporter, sugar porter (SP) family
    Nucleotide Protein
    Heading Accession and Version

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