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    yqgF ribonuclease H-like domain-containing nuclease [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947439, updated on 3-Dec-2024

    Summary

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    Official Symbol
    yqgF
    Official Full Name
    ribonuclease H-like domain-containing nuclease
    Primary source
    ECOCYC:G7525
    Locus tag
    b2949
    See related
    ASAP:ABE-0009672
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2944
    Summary
    AFMB Structural Genomics target Number 124 (http://afmb.cnrs-mrs.fr/article171.html). [More information is available at EcoGene: EG13290]. YqgF is an essential protein broadly conserved in bacteria that shows similarity to nucleases and may act as a Holliday junction resolvase (HJR) , though the monomeric structure suggests YqgF may not be a HJR . [More information is available at EcoCyc: G7525].
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    Genomic context

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    Sequence:
    NC_000913.3 (3093500..3093916)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene 16S rRNA m(3)U1498 methyltransferase Neighboring gene glutathione synthetase Neighboring gene DUF179 domain-containing protein YqgE Neighboring gene Type II/IV secretion system family protein Neighboring gene PLP homeostasis protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Novel essential gene Involved in 16S rRNA processing in Escherichia coli. Kurata T, et al. J Mol Biol, 2015 Feb 27. PMID 25545592
    2. Determination of the core of a minimal bacterial gene set. Gil R, et al. Microbiol Mol Biol Rev, 2004 Sep. PMID 15353568, Free PMC Article
    3. Backbone 1H, 15N and 13C resonance assignments of YqgF, an Escherichia coli protein of unknown structure and function. Liu D, et al. J Biomol NMR, 2002 Jun. PMID 12153044
    4. Identification of novel essential Escherichia coli genes conserved among pathogenic bacteria. Freiberg C, et al. J Mol Microbiol Biotechnol, 2001 Jul. PMID 11361082
    5. Conditional Epistatic Interaction Maps Reveal Global Functional Rewiring of Genome Integrity Pathways in Escherichia coli. Kumar A, et al. Cell Rep, 2016 Jan 26. PMID 26774489

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Taken together, these results suggest that YqgF is involved in anti-termination at Rho-dependent terminators in vivo.
      Title: Mutations in the essential Escherichia coli gene, yqgF, and their effects on transcription.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 3'-5'-DNA exonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hydrolase activity, acting on ester bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in DNA metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rRNA 5'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rRNA 5'-end processing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in rRNA 5'-end processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosome biogenesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within transcription antitermination EXP
    Inferred from Experiment
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ribonuclease H-like domain-containing nuclease
    NP_417424.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3093500..3093916
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417424.1 ribonuclease H-like domain-containing nuclease [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417424.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A7A3BVK8
      Conserved Domains (1) summary
      PRK00109
      Location:1 → 136
      PRK00109; Holliday junction resolvase RuvX
    Nucleotide Protein
    Heading Accession and Version

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