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    uxaC D-glucoronate/D-galacturonate isomerase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947599, updated on 17-Dec-2024

    Summary

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    Official Symbol
    uxaC
    Official Full Name
    D-glucoronate/D-galacturonate isomerase
    Primary source
    ECOCYC:G81
    Locus tag
    b3092
    See related
    ASAP:ABE-0010167
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3083; ygjX; ygjY; ygjZ
    Summary
    Uronate isomerase catalyzes the initial step of isomerization of the alduronic to the keturonic acid in the glucuronate and galacturonate degradation pathways. [More information is available at EcoCyc: G81].
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    Genomic context

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    Sequence:
    NC_000913.3 (3243329..3244741, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene inner membrane protein Neighboring gene D-altronate dehydratase Neighboring gene hexuronate transporter Neighboring gene DNA-binding transcriptional repressor ExuR

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The mechanism of the reaction catalyzed by uronate isomerase illustrates how an isomerase may have evolved from a hydrolase within the amidohydrolase superfamily. Nguyen TT, et al. Biochemistry, 2009 Sep 22. PMID 19678710, Free PMC Article
    2. [Studies of mutations in the uronic isomerase and altronic oxidoreductase structural genes of Escherichia coli K 12 (author's transl)]. Portalier RC, et al. Mol Gen Genet, 1974. PMID 4594010
    3. [Individuality of D glucuronate-ketol isomerase from K 12 Escherichia coli]. Novel G, et al. Biochimie, 1973. PMID 4594308
    4. Uronic acid metabolism in bacteria. I. Purification and properties of uronic acid isomerase in Escherichia coli. ASHWELL G, et al. J Biol Chem, 1960 Jun. PMID 13794771
    5. Studies on a D-galacturonic acid isomerase. TAKAGI Y, et al. Biochim Biophys Acta, 1959 Jan. PMID 13628636

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables glucuronate isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in D-galacturonate catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within D-galacturonate catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in D-glucuronate catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within D-glucuronate catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in glucuronate catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    D-glucoronate/D-galacturonate isomerase
    NP_417563.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3243329..3244741 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417563.1 D-glucoronate/D-galacturonate isomerase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417563.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A1V2G6N5
      Conserved Domains (1) summary
      PRK02925
      Location:1 → 468
      PRK02925; glucuronate isomerase; Reviewed
    Nucleotide Protein
    Heading Accession and Version

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