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    zntA Zn(2(+))/Cd(2(+))/Pb(2(+)) exporting P-type ATPase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947972, updated on 3-Dec-2024

    Summary

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    Official Symbol
    zntA
    Official Full Name
    Zn(2(+))/Cd(2(+))/Pb(2(+)) exporting P-type ATPase
    Primary source
    ECOCYC:EG12215
    Locus tag
    b3469
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3453; yhhO
    Summary
    HAD superfamily. [More information is available at EcoGene: EG12215]. The gene product of the yhhO gene, also referred to as zntA, is a P-type ATPase involved in the efflux of Pb(II), Cd(II), and Zn(II) . [More information is available at EcoCyc: EG12215].
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    Genomic context

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    Sequence:
    NC_000913.3 (3606451..3608649)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF2500 domain-containing protein YhhM Neighboring gene PF07947 family protein YhhN Neighboring gene sulfur transfer protein TusA Neighboring gene queuosine precursor transporter

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural Role of the First Four Transmembrane Helices in ZntA, a P(1B)-Type ATPase from Escherichia coli. Roberts CS, et al. Biochemistry, 2020 Dec 1. PMID 33190490
    2. The metal specificity and selectivity of ZntA from Escherichia coli using the acylphosphate intermediate. Hou Z, et al. J Biol Chem, 2003 Aug 1. PMID 12746428
    3. The nucleotide-binding domain of the Zn2+-transporting P-type ATPase from Escherichia coli carries a glycine motif that may be involved in binding of ATP. Okkeri J, et al. Biochem J, 2004 Jan 1. PMID 14510639, Free PMC Article
    4. Functional expression of a bacterial heavy metal transporter in Arabidopsis enhances resistance to and decreases uptake of heavy metals. Lee J, et al. Plant Physiol, 2003 Oct. PMID 14512517, Free PMC Article
    5. Introducing Wilson disease mutations into the zinc-transporting P-type ATPase of Escherichia coli. The mutation P634L in the 'hinge' motif (GDGXNDXP) perturbs the formation of the E2P state. Okkeri J, et al. Eur J Biochem, 2002 Mar. PMID 11874474

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structural Role of the First Four Transmembrane Helices in ZntA, a P1B-Type ATPase from Escherichia coli.
      Title: Structural Role of the First Four Transmembrane Helices in ZntA, a P(1B)-Type ATPase from Escherichia coli.
    2. Data suggest that a kinetically-controlled transcription model is sufficient to explain the observed regulation of intracellular free zinc concentration by ZntR and ZntA after zinc shock.
      Title: ZntR-mediated transcription of zntA responds to nanomolar intracellular free zinc.
    3. Selectivity in ZntA possibly results from differences in metal-binding geometry that produce different structural responses.
      Title: Metal-binding affinity of the transmembrane site in ZntA: implications for metal selectivity.
    4. (693) and D(714) are functionally essential and appear to contribute to the metal specificity of ZntA, most probably by being parts of the metal-binding site made up by the CPC motif
      Title: The metal-binding sites of the zinc-transporting P-type ATPase of Escherichia coli. Lys693 and Asp714 in the seventh and eighth transmembrane segments of ZntA contribute to the coupling of metal binding and ATPase activity.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    enables ATPase-coupled monoatomic cation transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables P-type cadmium transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables P-type cadmium transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables P-type ion transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables P-type zinc transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables P-type zinc transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cadmium ion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lead ion transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cadmium ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within detoxification of zinc ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within intracellular zinc ion homeostasis IC
    Inferred by Curator
    more info
    		 PubMed 
    acts_upstream_of_or_within lead ion transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in metal ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic cation transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to cadmium ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to lead ion IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to zinc ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within zinc ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in zinc ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within zinc ion transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Zn(2(+))/Cd(2(+))/Pb(2(+)) exporting P-type ATPase
    NP_417926.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3606451..3608649
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417926.1 Zn(2(+))/Cd(2(+))/Pb(2(+)) exporting P-type ATPase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417926.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8T5YGE6
      Conserved Domains (1) summary
      NF033775
      Location:1 → 732
      P_type_ZntA; Zn(II)/Cd(II)/Pb(II) translocating P-type ATPase ZntA
    Nucleotide Protein
    Heading Accession and Version

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