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    cysE serine acetyltransferase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948126, updated on 3-Dec-2024

    Summary

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    Official Symbol
    cysE
    Official Full Name
    serine acetyltransferase
    Primary source
    ECOCYC:EG10187
    Locus tag
    b3607
    See related
    ASAP:ABE-0011793
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3597
    Summary
    CysE forms a bienzyme complex with CysK. [More information is available at EcoGene: EG10187]. Serine acetyltransferase carries out the first step in the pathway of cysteine biosynthesis, converting L-serine into O-acetyl-L-serine. [More information is available at EcoCyc: EG10187].
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    Genomic context

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    Sequence:
    NC_000913.3 (3781741..3782562, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional dual regulator LldR Neighboring gene L-lactate dehydrogenase Neighboring gene tRNA (cytidine/uridine-2'-O)-ribose methyltransferase Neighboring gene glycerol-3-phosphate dehydrogenase Neighboring gene protein export chaperone SecB Neighboring gene reduced glutaredoxin 3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. PCR random mutagenesis into Escherichia coli serine acetyltransferase: isolation of the mutant enzymes that cause overproduction of L-cysteine and L-cystine due to the desensitization to feedback inhibition. Takagi H, et al. FEBS Lett, 1999 Jun 11. PMID 10386615
    2. Serine acetyltransferase of Escherichia coli: substrate specificity and feedback control by cysteine. Hindson VJ. Biochem J, 2003 Nov 1. PMID 12940772, Free PMC Article
    3. The structure and mechanism of serine acetyltransferase from Escherichia coli. Pye VE, et al. J Biol Chem, 2004 Sep 24. PMID 15231846
    4. Role of CysE in production of an extracellular signaling molecule in Providencia stuartii and Escherichia coli: loss of CysE enhances biofilm formation in Escherichia coli. Sturgill G, et al. J Bacteriol, 2004 Nov. PMID 15516574, Free PMC Article
    5. Random-order ternary complex reaction mechanism of serine acetyltransferase from Escherichia coli. Hindson VJ, et al. Biochemistry, 2003 Mar 18. PMID 12627979

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that bacterial serine acetyltransferase (CysE) is activated when bound to O-acetylserine sulfhydrylase-A sulfhydrylase (CysK).
      Title: Modulation of Escherichia coli serine acetyltransferase catalytic activity in the cysteine synthase complex.
    2. C-terminus of serine acetyltransferase, Ile 273, along with Glu 268 & Asp 271, was found to be essential for complex formation. Effects of O-acetyl-L-serine & sulfide on affinity for complex formation were also studied using surface plasmon technique.
      Title: On the interaction site of serine acetyltransferase in the cysteine synthase complex from Escherichia coli.
    3. required for the production of an extracellular signal molecule. CysE mutant formed biofilms at an accelerated rate compared to the wild type.
      Title: Role of CysE in production of an extracellular signaling molecule in Providencia stuartii and Escherichia coli: loss of CysE enhances biofilm formation in Escherichia coli.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables serine O-acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine O-acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables serine O-acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cysteine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cysteine biosynthetic process from serine IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cysteine biosynthetic process from serine IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cysteine biosynthetic process from serine IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to X-ray IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of cysteine synthase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cysteine synthase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serine acetyltransferase
    NP_418064.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3781741..3782562 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418064.1 serine acetyltransferase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418064.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A5N8HKQ3
      Conserved Domains (1) summary
      PRK11132
      Location:1 → 273
      cysE; serine acetyltransferase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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