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    nepI purine ribonucleoside exporter [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948213, updated on 3-Dec-2024

    Summary

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    Official Symbol
    nepI
    Official Full Name
    purine ribonucleoside exporter
    Primary source
    ECOCYC:EG11689
    Locus tag
    b3662
    See related
    ASAP:ABE-0011967
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3653; yicM
    Summary
    Overexpression of nepI increases resistance to inosine and guanosine. [More information is available at EcoGene: EG11689]. The NepI protein is a member of the major facilitator superfamily (MFS) of transporters . nepI encodes a purine ribonucleoside exporter. [More information is available at EcoCyc: EG11689].
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    Genomic context

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    Sequence:
    NC_000913.3 (3840549..3841739, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene lipoprotein-28 Neighboring gene uncharacterized protein YicS Neighboring gene DUF1198 domain-containing protein YicN Neighboring gene adenine transporter

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of a novel intracellularly activated gene from Salmonella enterica serovar typhi. Basso H, et al. Infect Immun, 2002 Oct. PMID 12228264, Free PMC Article
    2. The ETT2 gene cluster, encoding a second type III secretion system from Escherichia coli, is present in the majority of strains but has undergone widespread mutational attrition. Ren CP, et al. J Bacteriol, 2004 Jun. PMID 15150243, Free PMC Article
    3. The yicM (nepI) gene of Escherichia coli encodes a major facilitator superfamily protein involved in efflux of purine ribonucleosides. Gronskiy SV, et al. FEMS Microbiol Lett, 2005 Sep 1. PMID 16040204
    4. Microbial drug efflux proteins of the major facilitator superfamily. Saidijam M, et al. Curr Drug Targets, 2006 Jul. PMID 16842212
    5. The major facilitator superfamily. Saier MH Jr, et al. J Mol Microbiol Biotechnol, 1999 Nov. PMID 10943556

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. yicM encodes a purine ribonucleoside exporter
      Title: The yicM (nepI) gene of Escherichia coli encodes a major facilitator superfamily protein involved in efflux of purine ribonucleosides.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables purine nucleoside transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables purine nucleoside transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in purine nucleoside transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within purine nucleoside transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    purine ribonucleoside exporter

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3840549..3841739 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418118.2 purine ribonucleoside exporter [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418118.2

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S7JTD0
      Conserved Domains (1) summary
      PRK10213
      Location:1 → 394
      nepI; purine ribonucleoside efflux pump NepI
    Nucleotide Protein
    Heading Accession and Version

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