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    metB O-succinylhomoserine(thiol)-lyase/O-succinylhomoserine lyase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948434, updated on 3-Dec-2024

    Summary

    Official Symbol
    metB
    Official Full Name
    O-succinylhomoserine(thiol)-lyase/O-succinylhomoserine lyase
    Primary source
    ECOCYC:EG10582
    Locus tag
    b3939
    See related
    ASAP:ABE-0012887
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3931; met-1
    Summary
    Upregulated by GSNO in defined medium. [More information is available at EcoGene: EG10582].
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    Genomic context

    Sequence:
    NC_000913.3 (4128672..4129832)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative lipid-binding hydrolase YiiX Neighboring gene DNA-binding transcriptional repressor MetJ Neighboring gene fused aspartate kinase/homoserine dehydrogenase 2 Neighboring gene 5,10-methylenetetrahydrofolate reductase

    Genomic regions, transcripts, and products

    Genomic Sequence:
    NC_000913.3

    Bibliography

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables catalytic activity  
    enables cystathionine gamma-lyase activity  
    enables cystathionine gamma-synthase activity  
    enables cystathionine gamma-synthase activity PubMed 
    enables cystathionine gamma-synthase activity  
    enables pyridoxal phosphate binding  
    enables pyridoxal phosphate binding PubMed 
    enables pyridoxal phosphate binding  
    enables transferase activity  
    Process Evidence Code Pubs
    involved_in cysteine biosynthetic process via cystathionine  
    involved_in methionine biosynthetic process  
    acts_upstream_of_or_within methionine biosynthetic process PubMed 
    involved_in transsulfuration  
    involved_in transsulfuration  
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in cytoplasm  

    General protein information

    Preferred Names
    O-succinylhomoserine(thiol)-lyase/O-succinylhomoserine lyase
    NP_418374.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4128672..4129832
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418374.1 O-succinylhomoserine(thiol)-lyase/O-succinylhomoserine lyase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418374.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8H9W088
      Conserved Domains (1) summary
      PRK08045
      Location:1 → 386
      PRK08045; cystathionine gamma-synthase; Provisional
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