U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    nadR DNA-binding transcriptional repressor/NMN adenylyltransferase NadR [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948911, updated on 3-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    nadR
    Official Full Name
    DNA-binding transcriptional repressor/NMN adenylyltransferase NadR
    Primary source
    ECOCYC:EG11335
    Locus tag
    b4390
    See related
    ASAP:ABE-0014397
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK4382; nadI
    Summary
    The multifunctional protein "NAD regulator," NadR, has enzymatic as well as regulatory activity in the NAD biosynthetic pathway. [More information is available at EcoCyc: EG11335].
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Sequence:
    NC_000913.3 (4627315..4628547)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene phosphoserine phosphatase Neighboring gene DNA recombination protein Neighboring gene energy-dependent translational throttle protein EttA Neighboring gene soluble lytic murein transglycosylase

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Evolution of the NadR regulon in Enterobacteriaceae. Gerasimova AV, et al. J Bioinform Comput Biol, 2005 Aug. PMID 16078372
    2. Ribosylnicotinamide kinase domain of NadR protein: identification and implications in NAD biosynthesis. Kurnasov OV, et al. J Bacteriol, 2002 Dec. PMID 12446641, Free PMC Article
    3. Recognition of a gene involved in the regulation of nicotinamide adenine dinucleotide biosynthesis. Tritz GJ, et al. J Bacteriol, 1973 Apr. PMID 4349027, Free PMC Article
    4. Pyridine nucleotide cycle of Salmonella typhimurium: isolation and characterization of pncA, pncB, and pncC mutants and utilization of exogenous nicotinamide adenine dinucleotide. Foster JW, et al. J Bacteriol, 1979 Mar. PMID 220211, Free PMC Article
    5. Pyridine nucleotide cycle of Salmonella typhimurium: in vitro demonstration of nicotinamide mononucleotide deamidase and characterization of pnuA mutants defective in nicotinamide mononucleotide transport. Kinney DM, et al. J Bacteriol, 1979 Nov. PMID 387742, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nicotinamide-nucleotide adenylyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nicotinamide-nucleotide adenylyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nicotinamide-nucleotide adenylyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribosylnicotinamide kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in NAD biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in NAD biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to metal ion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within protein homotetramerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in pyridine nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to alkaline pH IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of adenylyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of catalytic complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    DNA-binding transcriptional repressor/NMN adenylyltransferase NadR
    NP_418807.4

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4627315..4628547
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418807.4 DNA-binding transcriptional repressor/NMN adenylyltransferase NadR [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418807.4

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A7A6VRZ5
      Conserved Domains (1) summary
      PRK08099
      Location:13 → 409
      PRK08099; multifunctional transcriptional regulator/nicotinamide-nucleotide adenylyltransferase/ribosylnicotinamide kinase NadR
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.