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    thrL thr operon leader peptide [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 944742, updated on 3-Dec-2024

    Summary

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    Official Symbol
    thrL
    Official Full Name
    thr operon leader peptide
    Primary source
    ECOCYC:EG11277
    Locus tag
    b0001
    See related
    ASAP:ABE-0000006
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0001
    Summary
    The ThrL leader peptide controls by attenuation the expression of the thrLABC operon, which encodes four out of the five enzymes of threonine biosynthesis pathway, in response to the threonine and isoleucine levels . [More information is available at EcoCyc: EG11277].
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    Genomic context

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    Sequence:
    NC_000913.3 (190..255)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene fused aspartate kinase/homoserine dehydrogenase 1 Neighboring gene homoserine kinase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Attenuation regulation in the thr operon of Escherichia coli K-12: molecular cloning and transcription of the controlling region. Lynn SP, et al. J Bacteriol, 1982 Oct. PMID 6811557, Free PMC Article
    2. DNA sequence change of a deletion mutation abolishing attenuation control of the threonine operon of E. coli K12. Parsot C, et al. Mol Gen Genet, 1982. PMID 6298575
    3. Initiation, pausing, and termination of transcription in the threonine operon regulatory region of Escherichia coli. Gardner JF. J Biol Chem, 1982 Apr 10. PMID 6277952
    4. Isolation and footprint analysis of the Escherichia coli thr leader paused transcription complex. Yang MT, et al. Nucleic Acids Res, 1991 Apr 11. PMID 1709279, Free PMC Article
    5. Regulation of the threonine operon: tandem threonine and isoleucine codons in the control region and translational control of transcription termination. Gardner JF. Proc Natl Acad Sci U S A, 1979 Apr. PMID 287010, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Gene Ontology Provided by EcoCyc

    Process Evidence Code Pubs
    involved_in threonine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within transcriptional attenuation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transcriptional attenuation by ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    thr operon leader peptide

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      190..255
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414542.1 thr operon leader peptide [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414542.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P0AD86
    Nucleotide Protein
    Heading Accession and Version

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