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    zapD cell division factor ZapD [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 944873, updated on 3-Dec-2024

    Summary

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    Official Symbol
    zapD
    Official Full Name
    cell division factor ZapD
    Primary source
    ECOCYC:EG12313
    Locus tag
    b0102
    See related
    ASAP:ABE-0000355
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0102; yacF
    Summary
    A mutation has been constructed . [More information is available at EcoCyc: EG12313].
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    Genomic context

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    Sequence:
    NC_000913.3 (111856..112599, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene 8-oxo-dGTP diphosphatase Neighboring gene DNA gyrase inhibitor YacG Neighboring gene dephospho-CoA kinase Neighboring gene protein YacM

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Crystallization and preliminary X-ray crystallographic analysis of Z-ring-associated protein (ZapD) from Escherichia coli. Son SH, et al. Acta Crystallogr F Struct Biol Commun, 2015 Feb. PMID 25664795, Free PMC Article
    2. Structure of the Z Ring-associated Protein, ZapD, Bound to the C-terminal Domain of the Tubulin-like Protein, FtsZ, Suggests Mechanism of Z Ring Stabilization through FtsZ Cross-linking. Schumacher MA, et al. J Biol Chem, 2017 Mar 3. PMID 28100778, Free PMC Article
    3. Structure and Mutational Analyses of Escherichia coli ZapD Reveal Charged Residues Involved in FtsZ Filament Bundling. Roach EJ, et al. J Bacteriol, 2016 Jun 1. PMID 27021560, Free PMC Article
    4. Identification of ZapD as a cell division factor that promotes the assembly of FtsZ in Escherichia coli. Durand-Heredia J, et al. J Bacteriol, 2012 Jun. PMID 22505682, Free PMC Article
    5. Tools for characterization of Escherichia coli genes of unknown function. Merlin C, et al. J Bacteriol, 2002 Aug. PMID 12142427, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ZapD acts as a molecular cross-linking reagent between FtsZ protofilaments to enhance FtsZ assembly
      Title: Structure of the Z Ring-associated Protein, ZapD, Bound to the C-terminal Domain of the Tubulin-like Protein, FtsZ, Suggests Mechanism of Z Ring Stabilization through FtsZ Cross-linking.
    2. ZapD and show it forms a symmetrical dimer with centrally located alpha-helices flanked by beta-sheet domains.
      Title: Structure and Mutational Analyses of Escherichia coli ZapD Reveal Charged Residues Involved in FtsZ Filament Bundling.
    3. Biochemical evidence indicates that ZapD directly interacts with FtsZ and promotes bundling of FtsZ protofilaments.
      Title: Identification of ZapD as a cell division factor that promotes the assembly of FtsZ in Escherichia coli.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in FtsZ-dependent cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in FtsZ-dependent cytokinesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within FtsZ-dependent cytokinesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within FtsZ-dependent cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell septum assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in division septum assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell division site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell division site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cell division factor ZapD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      111856..112599 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414644.1 cell division factor ZapD [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414644.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A775UU53
      Conserved Domains (1) summary
      COG4582
      Location:4 → 247
      ZapD; Cell division protein ZapD, interacts with FtsZ [Cell cycle control, cell division, chromosome partitioning]
    Nucleotide Protein
    Heading Accession and Version

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