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    ldcC lysine decarboxylase 2 [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 944887, updated on 3-Dec-2024

    Summary

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    Official Symbol
    ldcC
    Official Full Name
    lysine decarboxylase 2
    Primary source
    ECOCYC:G6094
    Locus tag
    b0186
    See related
    ASAP:ABE-0000633
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0185; ldc; ldcH
    Summary
    There are two lysine decarboxylases in Escherichia coli, encoded by the cadA and ldcC genes . [More information is available at EcoCyc: G6094].
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    Genomic context

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    Sequence:
    NC_000913.3 (209679..211820)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA polymerase III subunit alpha Neighboring gene acetyl-CoA carboxyltransferase subunit alpha Neighboring gene VOC domain-containing protein YaeR Neighboring gene tRNA(Ile)-lysidine synthetase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of a Whole-Cell Biotransformation Using a Constitutive Lysine Decarboxylase from Escherichia coli for the High-Level Production of Cadaverine from Industrial Grade L-Lysine. Shin J, et al. Appl Biochem Biotechnol, 2018 Aug. PMID 29374336
    2. Selenalysine as substrate of lysine decarboxylase. Blarzino C, et al. Ital J Biochem, 1977 Nov-Dec. PMID 344273
    3. Cadaverine biosynthesis contributes to decreased Escherichia coli susceptibility to antibiotics. Akhova A, et al. Res Microbiol, 2021 Nov-Dec. PMID 34543694
    4. Lysine decarboxylase assay by the pH-stat method. Vienozinskiene J, et al. Anal Biochem, 1985 Apr. PMID 3887985
    5. Stimulation of lysine decarboxylase production in Escherichia coli by amino acids and peptides. Cascieri T Jr, et al. Appl Microbiol, 1973 Dec. PMID 4588201, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cadaverine biosynthesis contributes to decreased Escherichia coli susceptibility to antibiotics.
      Title: Cadaverine biosynthesis contributes to decreased Escherichia coli susceptibility to antibiotics.
    2. This study reveals that EcLdcC is a promising whole-cell biocatalyst for the bio-based production of cadaverine from industrial grade L-lysine in comparison to EcCadA.
      Title: Characterization of a Whole-Cell Biotransformation Using a Constitutive Lysine Decarboxylase from Escherichia coli for the High-Level Production of Cadaverine from Industrial Grade L-Lysine.
    3. The structural principles of the LdcI-RavA interaction are being described using molecular modeling.
      Title: Assembly principles of a unique cage formed by hexameric and decameric E. coli proteins.
    4. N-terminus verified by Edman degradation on complete protein
      Title: The Escherichia coli ldcC gene encodes another lysine decarboxylase, probably a constitutive enzyme.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables carboxy-lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables lysine decarboxylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables lysine decarboxylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in amino acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lysine catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    lysine decarboxylase 2
    NP_414728.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      209679..211820
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414728.1 lysine decarboxylase 2 [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414728.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376FNX8, A0A8S7EC57
      Conserved Domains (1) summary
      PRK15399
      Location:1 → 713
      PRK15399; lysine decarboxylase
    Nucleotide Protein
    Heading Accession and Version

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