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    ivy periplasmic chaperone, inhibitor of vertebrate C-type lysozyme [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946530, updated on 17-Dec-2024

    Summary

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    Official Symbol
    ivy
    Official Full Name
    periplasmic chaperone, inhibitor of vertebrate C-type lysozyme
    Primary source
    ECOCYC:G6104
    Locus tag
    b0220
    See related
    ASAP:ABE-0000740
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0221; ykfE
    Summary
    Ivy acts as a homodimer that specifically binds and inhibits vertebrate C-type lysozyme, behaving like a slow tight binding inhibitor with a Ki of about 1 nM . [More information is available at EcoCyc: G6104].
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    Genomic context

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    Sequence:
    NC_000913.3 (240343..240816)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene 2-oxoglutaramate amidase Neighboring gene acyl-CoA dehydrogenase Neighboring gene D-sedoheptulose 7-phosphate isomerase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Protecting Gram-negative bacterial cell envelopes from human lysozyme: Interactions with Ivy inhibitor proteins from Escherichia coli and Pseudomonas aeruginosa. Liu Z, et al. Biochim Biophys Acta, 2015 Nov. PMID 25838125
    2. Role of the lysozyme inhibitor Ivy in growth or survival of Escherichia coli and Pseudomonas aeruginosa bacteria in hen egg white and in human saliva and breast milk. Deckers D, et al. Appl Environ Microbiol, 2008 Jul. PMID 18515493, Free PMC Article
    3. Structural evidence for lack of inhibition of fish goose-type lysozymes by a bacterial inhibitor of lysozyme. Kyomuhendo P, et al. J Mol Model, 2008 Sep. PMID 18491152
    4. Crystallization and preliminary crystallographic study of b0220, an 'ORFan' protein of unknown function from Escherichia coli. Abergel C, et al. Acta Crystallogr D Biol Crystallogr, 2000 Dec. PMID 11092949
    5. Escherichia coli ykfE ORFan gene encodes a potent inhibitor of C-type lysozyme. Monchois V, et al. J Biol Chem, 2001 May 25. PMID 11278658

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Conclude that differences in the electrostatic interactions at the binding interface between Ivy inhibitors and distinct lysozymes determine the strength of this interaction.
      Title: Protecting Gram-negative bacterial cell envelopes from human lysozyme: Interactions with Ivy inhibitor proteins from Escherichia coli and Pseudomonas aeruginosa.
    2. The RcsB and RcsF two-component system regulates expression of lysozyme inhibitors, Ivy and MliC.
      Title: The Rcs two-component system regulates expression of lysozyme inhibitors and is induced by exposure to lysozyme.
    3. N-terminus verified by Edman degradation on mature peptide
      Title: Escherichia coli ykfE ORFan gene encodes a potent inhibitor of C-type lysozyme.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables lysozyme inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within chaperone-mediated protein folding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in outer membrane-bounded periplasmic space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in periplasmic space IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    periplasmic chaperone, inhibitor of vertebrate C-type lysozyme

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      240343..240816
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414755.1 periplasmic chaperone, inhibitor of vertebrate C-type lysozyme [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414755.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A0H2V565, A0A0H2YVU7, A0A0H3EG38, A0A192CIK2, A0A1V2FMJ1, A0A2J1C1R2, A0A2T3TL51, A0A377DHY0, A0A454A182, A0A478T640, A0A6N4P228, A0A790HVY7, A0A828U5D8, A0A829L5F8, A0A8S7QR10, A0AA36P4D0, A0AAD2NXG0, A0AAI9B5W2, A0AAQ1Q6P6, A0AAU8ZWN7, B7MC72, B7MQ57, B7UJB3, F4STZ2, Q1RFV1
      Conserved Domains (1) summary
      PRK09993
      Location:5 → 157
      PRK09993; C-lysozyme inhibitor; Provisional
    Nucleotide Protein
    Heading Accession and Version

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