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    mhpD 2-hydroxypentadienoate hydratase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 944768, updated on 3-Dec-2024

    Summary

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    Official Symbol
    mhpD
    Official Full Name
    2-hydroxypentadienoate hydratase
    Primary source
    ECOCYC:M013
    Locus tag
    b0350
    See related
    ASAP:ABE-0001205
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0347; mhpS
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    Genomic context

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    Sequence:
    NC_000913.3 (372115..372924)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene 3-carboxyethylcatechol 2,3-dioxygenase Neighboring gene 2-hydroxy-6-ketonona-2,4-dienedioate hydrolase Neighboring gene acetaldehyde dehydrogenase (acetylating) MhpF Neighboring gene 4-hydroxy-2-oxovalerate aldolase Neighboring gene 3-hydroxyphenylpropionate/3-hydroxycinnamate:H(+) symporter

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Assembly of a 20-nm protein cage by Escherichia coli 2-hydroxypentadienoic acid hydratase. Montgomery MG, et al. J Mol Biol, 2010 Mar 12. PMID 20053352
    2. Overproduction, purification and properties of 2,3-dihydroxyphenylpropionate 1,2-dioxygenase from Escherichia coli. Bugg TD. Biochim Biophys Acta, 1993 Oct 6. PMID 8399388
    3. Catabolism of phenylpropionic acid and its 3-hydroxy derivative by Escherichia coli. Burlingame R, et al. J Bacteriol, 1983 Jul. PMID 6345502, Free PMC Article
    4. Isolation and characterization of Escherichia coli mutants defective for phenylpropionate degradation. Burlingame RP, et al. J Bacteriol, 1986 Oct. PMID 3531186, Free PMC Article
    5. Genetic characterization and expression in heterologous hosts of the 3-(3-hydroxyphenyl)propionate catabolic pathway of Escherichia coli K-12. Ferrández A, et al. J Bacteriol, 1997 Apr. PMID 9098055, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Pentameric 2-hydroxypentadienoic acid hydratase assembles to form a 20-nm-diameter particle comprising 60 protein subunits, arranged with 532 symmetry when crystallised at low pH in the presence of phosphate or sulphate ions.
      Title: Assembly of a 20-nm protein cage by Escherichia coli 2-hydroxypentadienoic acid hydratase.
    2. N-terminus verified by Edman degradation on mature peptide
      Title: Purification, characterisation and reaction mechanism of monofunctional 2-hydroxypentadienoic acid hydratase from Escherichia coli.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 2-oxopent-4-enoate hydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 2-oxopent-4-enoate hydratase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 2-oxopent-4-enoate hydratase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables manganese ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables manganese ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in 3-phenylpropionate catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    2-hydroxypentadienoate hydratase
    NP_414884.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      372115..372924
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414884.2 2-hydroxypentadienoate hydratase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414884.2

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A1X3JM23
      Conserved Domains (1) summary
      PRK11342
      Location:1 → 262
      mhpD; 2-keto-4-pentenoate hydratase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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