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    lon Lon protease [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945085, updated on 17-Dec-2024

    Summary

    Official Symbol
    lon
    Official Full Name
    Lon protease
    Primary source
    ECOCYC:EG10542
    Locus tag
    b0439
    See related
    ASAP:ABE-0001521
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    capR; deg; dir; ECK0433; lopA; muc
    Summary
    Lon dependent lethality is due to induction of yefM-yoeb toxin/antitoxin pair. [More information is available at EcoGene: EG10542]. Lon is an ATP-dependent protease responsible for degradation of misfolded proteins as well as a number of rapidly degraded regulatory proteins. [More information is available at EcoCyc: EG10542].
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    Genomic context

    Sequence:
    NC_000913.3 (458888..461242)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene ATP-dependent Clp protease proteolytic subunit Neighboring gene ATP-dependent Clp protease ATP-binding subunit ClpX Neighboring gene DNA-binding protein HU-beta Neighboring gene periplasmic folding chaperone

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding RCA
    inferred from Reviewed Computational Analysis
    more info
    PubMed 
    enables ATP hydrolysis activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP-dependent peptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ATP-dependent peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables peptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables serine-type endopeptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables serine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables serine-type peptidase activity RCA
    inferred from Reviewed Computational Analysis
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      458888..461242
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414973.1 Lon protease [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414973.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376X353
      Conserved Domains (1) summary
      PRK10787
      Location:1784
      PRK10787; DNA-binding ATP-dependent protease La; Provisional