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    ompT omptin family outer membrane protease OmpT [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945185, updated on 17-Dec-2024

    Summary

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    Official Symbol
    ompT
    Official Full Name
    omptin family outer membrane protease OmpT
    Primary source
    ECOCYC:EG10673
    Locus tag
    b0565
    See related
    ASAP:ABE-0001931
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0557
    Summary
    Mg(2+) stimulon-PhoPQ regulon, EvgAS-PhoPQ cascade enhanced-expression subset. [More information is available at EcoGene: EG10673]. OmpT is an outer membrane protease with specificity for paired basic residues ; detailed studies on substrate specificity have been performed . [More information is available at EcoCyc: EG10673].
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    Genomic context

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    Sequence:
    NC_000913.3 (584680..585633, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene protein TfaX Neighboring gene DNA-binding transcriptional activator AppY Neighboring gene DNA-binding transcriptional activator EnvY Neighboring gene putative exopolysaccharide secretion system auxiliary component

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. In vitro folding, purification and characterization of Escherichia coli outer membrane protease ompT. Kramer RA, et al. Eur J Biochem, 2000 Feb. PMID 10651827
    2. OmpT: molecular dynamics simulations of an outer membrane enzyme. Baaden M, et al. Biophys J, 2004 Nov. PMID 15315948, Free PMC Article
    3. Investigation into the interaction of the bacterial protease OmpT with outer membrane lipids and biological activity of OmpT:lipopolysaccharide complexes. Brandenburg K, et al. Eur Biophys J, 2005 Feb. PMID 15241571
    4. Utilization of Escherichia coli outer-membrane endoprotease OmpT variants as processing enzymes for production of peptides from designer fusion proteins. Okuno K, et al. Appl Environ Microbiol, 2004 Jan. PMID 14711628, Free PMC Article
    5. Distribution and genetic association of putative uropathogenic virulence factors iroN, iha, kpsMT, ompT and usp in Escherichia coli isolated from urinary tract infections in Japan. Kanamaru S, et al. J Urol, 2003 Dec. PMID 14634457

    See all (73) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results suggest that OmpT plays a multifaceted role in pathogenesis of urinary tract infection, including increased bacterial adhesiveness/invasiveness, formation of intracellular bacterial communities and upregulated proinflammatory cytokines.
      Title: Role of uropathogenic Escherichia coli outer membrane protein T in pathogenesis of urinary tract infection.
    2. N-terminus verified by Edman degradation on mature peptide
      Title: Extraction of membrane proteins by differential solubilization for separation using two-dimensional gel electrophoresis.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables aspartic-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables endopeptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables serine-type endopeptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within proteolysis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    omptin family outer membrane protease OmpT
    NP_415097.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      584680..585633 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415097.1 omptin family outer membrane protease OmpT [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415097.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376DE95, G9FSR4
      Conserved Domains (1) summary
      PRK10993
      Location:1 → 317
      PRK10993; omptin family outer membrane protease
    Nucleotide Protein
    Heading Accession and Version

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