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    cusA copper/silver export system RND permease [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945191, updated on 3-Dec-2024

    Summary

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    Official Symbol
    cusA
    Official Full Name
    copper/silver export system RND permease
    Primary source
    ECOCYC:EG12367
    Locus tag
    b0575
    See related
    ASAP:ABE-0001971
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0567; ybdE
    Summary
    cusA is in the cusCFBA Cu and Ag efflux operon regulated by Cu and Ag. [More information is available at EcoGene: EG12367]. CusA is a member of the Resistance-Nodulation-Cell Division (RND) Transporter Superfamily and is involved in the detoxification of copper and silver ions in Escherichia coli as part of the CusCFBA copper/silver efflux system. [More information is available at EcoCyc: EG12367].
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    Genomic context

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    Sequence:
    NC_000913.3 (598714..601857)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene copper/silver export system periplasmic binding protein Neighboring gene copper/silver export system membrane fusion protein Neighboring gene phenylalanine:H(+) symporter PheP Neighboring gene miniconductance mechanosensitive channel YbdG

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cryo-EM Structures of CusA Reveal a Mechanism of Metal-Ion Export. Moseng MA, et al. mBio, 2021 Apr 5. PMID 33820823, Free PMC Article
    2. Crystal structures of the CusA efflux pump suggest methionine-mediated metal transport. Long F, et al. Nature, 2010 Sep 23. PMID 20865003, Free PMC Article
    3. Differences between CusA and AcrB crystallisation highlighted by protein flexibility. Deniaud A, et al. PLoS One, 2009 Jul 10. PMID 19593437, Free PMC Article
    4. Alternative periplasmic copper-resistance mechanisms in Gram negative bacteria. Pontel LB, et al. Mol Microbiol, 2009 Jul. PMID 19538445
    5. Cloning and sequencing of the pheP gene, which encodes the phenylalanine-specific transport system of Escherichia coli. Pi J, et al. J Bacteriol, 1991 Jun. PMID 1711024, Free PMC Article

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cryo-EM Structures of CusA Reveal a Mechanism of Metal-Ion Export.
      Title: Cryo-EM Structures of CusA Reveal a Mechanism of Metal-Ion Export.
    2. CusA forms a mixture of quaternary structures (from monomer to heavy oligomer) in detergent solution.
      Title: Oligomeric behavior of the RND transporters CusA and AcrB in micellar solution of detergent.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables copper ion binding IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables copper ion transmembrane transporter activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables monoatomic cation transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables silver ion transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables xenobiotic transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within copper ion export IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in copper ion export NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in copper ion transmembrane transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in copper ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within detoxification of copper ion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within intracellular copper ion homeostasis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in monoatomic cation transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within plasma membrane copper ion transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within response to copper ion IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to copper ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to silver ion IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to silver ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to toxic substance NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in silver ion transmembrane transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within silver ion transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in xenobiotic transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    copper/silver export system RND permease

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      598714..601857
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415107.1 copper/silver export system RND permease [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415107.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8T5YGB6
      Conserved Domains (1) summary
      TIGR00914
      Location:1 → 1047
      2A0601; heavy metal efflux pump, CzcA family
    Nucleotide Protein
    Heading Accession and Version

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