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    moaA GTP 3',8'-cyclase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945392, updated on 3-Dec-2024

    Summary

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    Official Symbol
    moaA
    Official Full Name
    GTP 3',8'-cyclase
    Primary source
    ECOCYC:EG11595
    Locus tag
    b0781
    See related
    ASAP:ABE-0002669
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    bisA; chlA; chlA1; ECK0770; narA
    Summary
    The moaA 5' UTR has a molybdenum cofactor (Moco) sensitive riboswitch. [More information is available at EcoGene: EG11595]. Molybdenum and tungsten cofactors of all enzymes, with the exception of nitrogenase, that require one or the other of the other for activity are present in an oxidized state as molybdate or tungstate ions that are chelated by the cis-dithiolene moiety of a molybdenum cofactor. [More information is available at EcoCyc: EG11595].
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    Genomic context

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    Sequence:
    NC_000913.3 (817044..818033)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene UvrABC excision nuclease subunit B Neighboring gene putative transferase YbhK Neighboring gene protein MoaB Neighboring gene cyclic pyranopterin monophosphate synthase Neighboring gene molybdopterin synthase sulfur carrier subunit

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A widespread riboswitch candidate that controls bacterial genes involved in molybdenum cofactor and tungsten cofactor metabolism. Regulski EE, et al. Mol Microbiol, 2008 May. PMID 18363797, Free PMC Article
    2. Positive selection of mutants with deletions of the gal-chl region of the Salmonella chromosome as a screening procedure for mutagens that cause deletions. Alper MD, et al. J Bacteriol, 1975 Jan. PMID 1090571, Free PMC Article
    3. Synthesis of nitrate reductase components in chlorate-resistant mutants of Escherichia coli. MacGregor CH. J Bacteriol, 1975 Mar. PMID 1090592, Free PMC Article
    4. The tetrahydropyranopterin structure of the sulfur-free and metal-free molybdenum cofactor precursor. Santamaria-Araujo JA, et al. J Biol Chem, 2004 Apr 16. PMID 14761975
    5. Regulation of the chlA locus of Escherichia coli K12: involvement of molybdenum cofactor. Baker KP, et al. Mol Microbiol, 1991 Apr. PMID 1906967

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on complete protein
      Title: Molecular genetic analysis of the moa operon of Escherichia coli K-12 required for molybdenum cofactor biosynthesis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 4 iron, 4 sulfur cluster binding ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables GTP 3',8'-cyclase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP 3',8'-cyclase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP 3',8'-cyclase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables S-adenosyl-L-methionine binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cyclic pyranopterin monophosphate synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Mo-molybdopterin cofactor biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Mo-molybdopterin cofactor biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within Mo-molybdopterin cofactor biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to heat IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    GTP 3',8'-cyclase
    NP_415302.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      817044..818033
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415302.1 GTP 3',8'-cyclase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415302.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A454A2F5
      Conserved Domains (1) summary
      PRK00164
      Location:1 → 329
      moaA; GTP 3',8-cyclase MoaA
    Nucleotide Protein
    Heading Accession and Version

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