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    deoR DNA-binding transcriptional repressor DeoR [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945453, updated on 3-Dec-2024

    Summary

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    Official Symbol
    deoR
    Official Full Name
    DNA-binding transcriptional repressor DeoR
    Primary source
    ECOCYC:EG10223
    Locus tag
    b0840
    See related
    ASAP:ABE-0002862
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0830; nucR
    Summary
    DeoR is a DNA-binding transcriptional regulator that is involved in the negative regulation of genes that encode nucleotide catabolism (deoCABD, nupG, and tsx). [More information is available at EcoCyc: EG10223].
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    Genomic context

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    Sequence:
    NC_000913.3 (881976..882734, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene aldose sugar dehydrogenase YliI Neighboring gene glutathione S-transferase GstB Neighboring gene D-alanyl-D-alanine carboxypeptidase DacC Neighboring gene undecaprenyl pyrophosphate phosphatase Neighboring gene multidrug efflux pump MdfA/Na(+):H(+) antiporter/K(+):H(+) antiporter

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Design, synthesis, biological evaluation and pharmacokinetics of bis(hydroxyphenyl) substituted azoles, thiophenes, benzenes, and aza-benzenes as potent and selective nonsteroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1). Bey E, et al. J Med Chem, 2008 Nov 13. PMID 18855374
    2. Multiple regulation of nucleoside catabolizing enzymes: regulation of the deo operon by the cytR and deoR gene products. Hammer-Jespersen K, et al. Mol Gen Genet, 1975. PMID 171553
    3. DeoR repression at-a-distance only weakly responds to changes in interoperator separation and DNA topology. Dandanell G. Nucleic Acids Res, 1992 Oct 25. PMID 1437558, Free PMC Article
    4. The structure of tandem regulatory regions in the deo operon of Escherichia coli K12. Valentin-Hansen P, et al. EMBO J, 1982. PMID 16453417, Free PMC Article
    5. Long-distance deoR regulation of gene expression in Escherichia coli. Dandanell G, et al. Ann N Y Acad Sci, 1991 Dec 27. PMID 1809188

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ligand-activated transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of DNA-templated transcription initiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DNA-binding transcriptional repressor DeoR

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      881976..882734 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415361.1 DNA-binding transcriptional repressor DeoR [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415361.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A7A6JM63
      Conserved Domains (1) summary
      PRK10681
      Location:1 → 252
      PRK10681; DNA-binding transcriptional repressor DeoR; Provisional
    Nucleotide Protein
    Heading Accession and Version

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