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    gloC hydroxyacylglutathione hydrolase GloC [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945551, updated on 17-Dec-2024

    Summary

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    Official Symbol
    gloC
    Official Full Name
    hydroxyacylglutathione hydrolase GloC
    Primary source
    ECOCYC:G6475
    Locus tag
    b0927
    See related
    ASAP:ABE-0003147
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0918; ycbL
    Summary
    AFMB Structural Genomics target Number 127 (http://afmb.cnrs-mrs.fr/article171.html). [More information is available at EcoGene: EG13704].
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    Genomic context

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    Sequence:
    NC_000913.3 (983650..984297)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene L,D-transpeptidase LdtD Neighboring gene peptidoglycan L,D-endopeptidase Neighboring gene aspartate aminotransferase Neighboring gene outer membrane porin F

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Deciphering the role of the type II glyoxalase isoenzyme YcbL (GlxII-2) in Escherichia coli. Reiger M, et al. FEMS Microbiol Lett, 2015 Jan. PMID 25670698
    2. Localization, annotation, and comparison of the Escherichia coli K-12 proteome under two states of growth. Lopez-Campistrous A, et al. Mol Cell Proteomics, 2005 Aug. PMID 15911532
    3. Protein abundance profiling of the Escherichia coli cytosol. Ishihama Y, et al. BMC Genomics, 2008 Feb 27. PMID 18304323, Free PMC Article
    4. A functional update of the Escherichia coli K-12 genome. Serres MH, et al. Genome Biol, 2001. PMID 11574054, Free PMC Article
    5. The binary protein-protein interaction landscape of Escherichia coli. Rajagopala SV, et al. Nat Biotechnol, 2014 Mar. PMID 24561554, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. findings show that YcbL (gloC/GlxII-2) acts as an accessory type II glyoxylase in E. coli; the two isoenzymes have additive effects and ensure maximal methylglyoxal degradation
      Title: Deciphering the role of the type II glyoxalase isoenzyme YcbL (GlxII-2) in Escherichia coli.
    2. YcbL, now designated as gloC/GlxII-2, is a type II glyoxylase.
      Title: Deciphering the role of the type II glyoxalase isoenzyme YcbL (GlxII-2) in Escherichia coli.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydroxyacylglutathione hydrolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hydroxyacylglutathione hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to toxic substance IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    hydroxyacylglutathione hydrolase GloC
    NP_415447.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      983650..984297
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415447.1 hydroxyacylglutathione hydrolase GloC [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415447.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376FPQ1
      Conserved Domains (1) summary
      cd07737
      Location:3 → 192
      YcbL-like_MBL-fold; Salmonella enterica serovar typhimurium YcbL and related proteins; MBL-fold metallo hydrolase domain
    Nucleotide Protein
    Heading Accession and Version

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