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    hflD lysogenization regulator [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945693, updated on 17-Dec-2024

    Summary

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    Official Symbol
    hflD
    Official Full Name
    lysogenization regulator
    Primary source
    ECOCYC:EG11345
    Locus tag
    b1132
    See related
    ASAP:ABE-0003812
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1118; hslZ; ycfC
    Summary
    hflD is a non-essential gene. [More information is available at EcoGene: EG11345]. hflD belongs to an operon with purB, which is involved in methionine synthesis . hflD encodes an inner membrane-localized protein responsible for directly interacting with protein CII of bacteriophage , making it more vulnerable to proteolysis by FtsH, leading to increased lysogenization frequency of . [More information is available at EcoCyc: EG11345].
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    Genomic context

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    Sequence:
    NC_000913.3 (1191990..1192631, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene sensor histidine kinase PhoQ Neighboring gene DNA-binding transcriptional dual regulator PhoP Neighboring gene adenylosuccinate lyase Neighboring gene tRNA-specific 2-thiouridylase Neighboring gene phosphatase NudJ

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. HflD, an Escherichia coli protein involved in the lambda lysis-lysogeny switch, impairs transcription activation by lambdaCII. Parua PK, et al. Arch Biochem Biophys, 2010 Jan 15. PMID 19853572
    2. Revisiting the lysogenization control of bacteriophage lambda. Identification and characterization of a new host component, HflD. Kihara A, et al. J Biol Chem, 2001 Apr 27. PMID 11278968
    3. The purB gene of Escherichia coli K-12 is located in an operon. Green SM, et al. Microbiology (Reading), 1996 Nov. PMID 8969519
    4. Escherichia coli purB gene: cloning, nucleotide sequence, and regulation by purR. He B, et al. J Bacteriol, 1992 Jan. PMID 1729205, Free PMC Article
    5. Autoregulation of PurR repressor synthesis and involvement of purR in the regulation of purB, purC, purL, purMN and guaBA expression in Escherichia coli. Meng LM, et al. Eur J Biochem, 1990 Jan 26. PMID 2404765

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within response to heat IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    colocalizes_with cytoplasmic side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    lysogenization regulator

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1191990..1192631 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415650.1 lysogenization regulator [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415650.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376MAZ3, A0A5B9AKR3
      Conserved Domains (1) summary
      PRK00218
      Location:1 → 209
      PRK00218; lysogenization regulator HflD
    Nucleotide Protein
    Heading Accession and Version

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