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    clcB putative chloride:H(+) antiporter ClcB [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947179, updated on 3-Dec-2024

    Summary

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    Official Symbol
    clcB
    Official Full Name
    putative chloride:H(+) antiporter ClcB
    Primary source
    ECOCYC:G6850
    Locus tag
    b1592
    See related
    ASAP:ABE-0005317
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1587; mriT; ynfJ
    Summary
    ClcA and ClcB encode redundant chloride channels. single mutants have no phenotype. [More information is available at EcoGene: EG13848]. The ClC family is the most ubiquitously expressed of all classes of chloride channels established thus far . [More information is available at EcoCyc: G6850].
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    Genomic context

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    Sequence:
    NC_000913.3 (1665315..1666571)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative menaquinol dehydrogenase Neighboring gene redox enzyme maturation protein DmsD Neighboring gene dethiobiotin synthetase BidA Neighboring gene DNA-binding transcriptional repressor Mlc Neighboring gene putative DNA-binding transcriptional regulator YnfL

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Discovery of potent CLC chloride channel inhibitors. Matulef K, et al. ACS Chem Biol, 2008 Jul 18. PMID 18642799, Free PMC Article
    2. A decade of CLC chloride channels: structure, mechanism, and many unsettled questions. Maduke M, et al. Annu Rev Biophys Biomol Struct, 2000. PMID 10940254
    3. Secondary active transport mediated by a prokaryotic homologue of ClC Cl- channels. Accardi A, et al. Nature, 2004 Feb 26. PMID 14985752
    4. A biological role for prokaryotic ClC chloride channels. Iyer R, et al. Nature, 2002 Oct 17. PMID 12384697
    5. High-level expression, functional reconstitution, and quaternary structure of a prokaryotic ClC-type chloride channel. Maduke M, et al. J Gen Physiol, 1999 Nov. PMID 10539975, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables chloride channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chloride channel activity RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    enables voltage-gated chloride channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to acidic pH EXP
    Inferred from Experiment
    more info
    		 PubMed 
    acts_upstream_of_or_within chloride transmembrane transport RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    involved_in chloride transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to acidic pH IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of chloride channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    putative chloride:H(+) antiporter ClcB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1665315..1666571
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416109.2 putative chloride:H(+) antiporter ClcB [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416109.2

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      A7ZM51, B1IQZ8, B7L5E4, B7LZY4
      UniProtKB/TrEMBL
      A0A037Y855, A0A140N8Z7, A0A7U9IZ24, A0A836ZAW8, A0AAE9R8G2, A0AAN3V440, W1EXM9
      Conserved Domains (1) summary
      PRK01610
      Location:1 → 418
      PRK01610; putative voltage-gated ClC-type chloride channel ClcB; Provisional
    Nucleotide Protein
    Heading Accession and Version

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